Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Morphological Effects of Penicillin on Bacteria

Abstract

WHILE working with Chain, Florey and others on the inhibition of bacterial growth by penicillin1, I noticed that concentrations of less than full inhibiting power caused a change in the appearance of the growth of Cl. welchii in fluid media. The normal uniform turbidity was replaced by a flocculent growth with a heavy deposit. Microscopical examination showed an extreme elongation of the majority of the cells, which took the form of unsegmented filaments ten or more times longer than the average normal cell.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy article

Get time limited or full article access on ReadCube.

$32.00

All prices are NET prices.

References

  1. Lancet, 226 (1940).

  2. Brit. Med. J., 2, 16 (1904).

  3. J. Inf. Dis., 64, 59 (1939).

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and Permissions

About this article

Cite this article

GARDNER, A. Morphological Effects of Penicillin on Bacteria. Nature 146, 837–838 (1940). https://doi.org/10.1038/146837b0

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/146837b0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing