Letter | Published:

Amine Oxidase and Benzedrine

Nature volume 145, pages 2627 (06 January 1940) | Download Citation



EXPERIMENTS which we have carried out during recent years seem to be of general interest in connexion with the observation reported by Mann and Quastel1 on the effect of benzedrine (β-phenylisopropylamine) on the metabolism of the central nervous system. First, it now seems possible to relate the action of the drug to an in vitro effect on one of the enzymic systems in the body; secondly, we can in this instance relate the action of the drug to its chemical structure. The effect on metabolism finds its explanation in the inhibitor action of β-phenylisopropylamine and its derivatives on amine oxidase. This effect was first described for ephedrine2, but it was shown soon afterwards that ephedrine shared it with all other derivatives of β-phenylisopropylamine that were examined3.

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  1. 1.

    and , NATURE, 144, 943 (1939).

  2. 2.

    , and , Biochem. J., 31, 2187 (1937).

  3. 3.

    , J. Physiol., 93, 7P (1938).

  4. 4.

    , , and , Skand. Arch. Physiol., 79, 258 (1938).

  5. 5.

    , Amer. J. Physiol., 126, 420 (1939).

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  1. Physiological Laboratory, Cambridge. Dec. 8.



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