Abstract
DURING the course of experiments in which rats were given graded amounts of vitamin A, it was noticed that by 50 days the incisor teeth of animals on daily doses of from to I. I. U. had lost the deep orange pigment in the enamel, the teeth of animals receiving larger doses being at this stage normal. But, if these latter rats were allowed to live longer, it was found that daily doses of 2–3 I.U. of vitamin A, which were adequate to produce normal teeth at 50 days, appeared insufficient when the animals were older, since later their teeth also gradually lost their pigment. It was therefore decided to investigate this point more closely and to examine the teeth histologically.
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References
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Schour, I., Smith, M. C., and Hoffman, M. M., Proc. Soc. Exp. Biol., 39, 447 (1938).
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Guilbert, H. R., and Hart, G. H., J. Nutrit., 10, 409 (1935).
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IRVING, J., RICHARDS, M. Influence of Age upon the Requirement of Vitamin A. Nature 144, 908–909 (1939). https://doi.org/10.1038/144908c0
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DOI: https://doi.org/10.1038/144908c0
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