Abstract
Ochoa and Peters1 found cocarboxylase decreased in tissues of pigeons fed on a diet deficient in vitamin B1. Axelrod and Elvehjem2 reported a diminution of cozymase in tissues of animals on a nicotinic acid free diet. We now find a similar diminution in the flavin-adenine-dinucleotide content of boiled extracts of tissues from rats fed on a diet deficient in flavin. The rats (average weight 35 gm.) were fed a synthetic diet of rice starch, casein (alcohol extracted), salt mixture, supplemented by cod liver oil, crystalline vitamin B1 hydrochloride, a 50 per cent alcohol yeast concentrate3, and a liver filtrate from a previous fuller's earth and franconite adsorption. These supplements were flavin-free.
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References
Ochoa and Peters., Biochem. J., 32. 1501 (1938).
Axelrod and Elvehjem., NATURE, 143, 281, (1939).
Kinnersley, O'Brien, Peters and Reader., Biochem. J., 27, 225, (1933).
Warburg and Christian., Biochem. Z., 293, 150, (1938).
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OCHOA, S., ROSSITER, R. Flavin-Adenine-Dinucleotide in Tissues of Rats on Diet Deficient in Flavin. Nature 144, 787 (1939). https://doi.org/10.1038/144787a0
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DOI: https://doi.org/10.1038/144787a0
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