Abstract
THE metabolism of the fats in tumours has been little studied. Haven1, feeding elaidin to rats, the method used by Sinclair2 in classifying phospholipids into the metabolic and the non-metabolic type, found that the phospholipids of tumours are mainly of the non-metabolic type, having to do with cellular structure rather than with the burning of fatty acids for energy. According to Kisch3, the Jensen sarcoma does not oxidize the low fatty acids. I have observed4 that the oxygen uptake of slices of various experimental and human tumours is not increased when saturated and unsaturated monocarboxylic fatty acids in the form of sodium salts are added to the medium, and that in no instance were acetone (ketone) bodies formed. The (β-hydroxybutyric acid, on the other hand, is oxidized into aceto-acetic acid.
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References
Haven, F. L., J. Biol. Chem., 118, 111, (1937).
Sinclair, R. G., J. Biol. Chem., 111, 515, (1935).
Kisch, B., Biochem. Z., 253, 379, (1932).
Ciarand, E., Amer. J. Cancer, 32, 501, (1938).
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CIARANFI, E. Oxidation of Methyl Esters of Monocarboxylic Fatty Acids by Normal and Neoplastic Tissue. Nature 144, 751 (1939). https://doi.org/10.1038/144751a0
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DOI: https://doi.org/10.1038/144751a0
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