Abstract
IT has been demonstrated that a riboflavin deficiency in the rat produces a marked derangement in those enzyme systems which are involved in the oxidation of certain intermediates of carbohydrate metabolism (Axelrod and Elvehjem, unpublished results). The possible effects of such a deficiency upon the metabolism of amino-acids have been suggested by the discovery of Warburg and Christian1that the prosthetic group of the d-amino-acid oxidase of Krebs2 is a flavin-adenine dinucleotide.
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References
Warburg, O., and Christian, W., Biochem. Z., 298, 150, (1938).
Krebs, H., Z. physiol. Chem., 217, 191, (1933).
Elvehjem, C. A., Koehn, C. J., and Oleson, J. J., J. Biol. Chem., 115, 707, (1936).
Snell, E., and Strong, F., Ind. and Eng. Chem., ii, 346 (1939).
Ball, E. G., Science, 88, 131, (1938).
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AXELROD, A., SOBER, H. & ELVEHJEM, C. Reduction of the d-Amino-Acid Oxidase Content of Rat Tissues in Riboflavin Deficiency. Nature 144, 670–671 (1939). https://doi.org/10.1038/144670a0
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DOI: https://doi.org/10.1038/144670a0
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