Abstract
IN previous reports1 it has been demonstrated that the sex hormones (œstrone, progesterone) are rapidly rendered inactive in the organism. If a rat is injected with 1,000 I.U. œstrone no more than 1–2 per cent of this substance can be recovered from the organism by organic solvents after a period of forty-eight hours. In contradistinction to this, the hormono esters (œstronebenzoate, œstradiolbenzoate) are very largely recovered. These findings have been corroborated by Laqueur2, who was able to demonstrate at the same time that the hormone esters remained deposited at the site of injection. They do not undergo slow decomposition in the blood, but are slowly absorbed from the site of injection.
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References
Zondek, B., Lancet, 227, 356, (1938):Scand. Arch. Physiol., 70, 133, (1934); NATURE, 143, 282, (1939).
Dingemanse, E., and Laqueur, E., Amer. J. Obst. and Gyn., 33, 1000 (1937): Frank Anniversary Volume.
Dodds, E. C., Golberg, L., Lawson, W. and Robinson, R., NATURE, 141, 247, (1938).
Zondek, B., and Bergmann, E., Biochem. J., 32. 641 (1938).
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ZONDEK, B., SULMAN, F. Inactivation of Diethylstilbœstrol in the Organism. Nature 144, 596–597 (1939). https://doi.org/10.1038/144596b0
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DOI: https://doi.org/10.1038/144596b0
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