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Production of Intercellular Hormones by Mechanical Injury

Abstract

PREVIOUS papers from this laboratory have demonstrated the production of proliferation-promoting factors (intercellular wound hormones) by cell aggregates subjected to lethal ultra-violet or X-rays1, heteroauxin2, and carbon dioxide3. These factors are evidently produced by living cells as a response to injury, since the maximum production of the hormones precedes the maximum rate of killing3.

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References

  1. Fardon, Norris, Loofbourow and Ruddy, NATURE, 139, 589 (1937); Sperti, Loofbourow and Dwyer, ibid., 140, 643 (1937); Studies Inst. Divi Thomae, 1, 163 (1937): Fardon, Carroll and Ruddy, ibid., 1, 17 (1937); Loofbourow, Dwyer and Morgan, ibid., 2, 137 (1938).

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  2. Loofbourow and Dwyer, Science, 88, 191 (1938); Studies Inst. Divi Thomae, in the press.

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  3. Loofbourow and Dwyer, NATURE, 143, 725 (1939).

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  4. Cook, Loofbourow and Stimson, 10th Internat. Congress of Chemistry, Rome, May 1938; Loofbourow, Cook and Stimson, NATURE, 142, 573 (1938).

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LOOFBOUROW, J., COOK, E., DWYER, C. et al. Production of Intercellular Hormones by Mechanical Injury. Nature 144, 553–554 (1939). https://doi.org/10.1038/144553a0

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