Abstract
IN recent years, several research workers have studied the problem, whether cancer of the skin in the tropics could be caused by carcinogenic substances formed in the skin after strong irradiation and whether the high percentage of cancer of the stomach in northern regions was connected with the usual diet and its preparation (for example, heating of fats). In a number of communications, Roffo1 has proved the carcinogenic action by the ultra-violet rays of sunlight, and his results have been corroborated by other authors2. He has put forward, too, the theory3 that a carcinogenic substance may be formed by the action of ultra-violet rays from cholesterine, which accumulates in the skin under the influence of the irradiation. Roffo has tried to strengthen this view by experiments in vitro with cholesterine; however, a definite reaction product has not yet been isolated and, moreover, the chemical evidence given is not convincing4.
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References
Roffo, A. H., Bol. Inst. Med. Exp. Estud. Cancer(1933–1938), compare Z. Krebsf., 47, 473 (1938).
See literature cited by Bergman, W., Z. Krebsf., 48, 546 (1939).
Roffo, A. H., Z. Krebsf., 47, 473 (1938).
Compare the detailed critical survey by Bergmann, loc. cit. 2.
Waterman, N., Conference Lecuwenhock-Vereeniging V. 86, Paris, 1937 (in details still to be published).
Waterman, N., Acta Cancrologica ii, 5/6, 375 (1936); Nederl. Tijdschr. Geneesk., 81, 1273 (1937); Acta brevia neerlandica, 7, 18 (1937) and loc. cit. 5.
Roffo, A. H., loc. cit. 3.
Domagk, G., Z. Krebsf., 48, 284 (1939).
Widmark, E. M. P., NATURE, 143, 984 (1939).
Compare Dimroth, K., Trautman, G., Ber. 69, 669 (1930). (Formation of a cholestadiene from 7-hydroxy-cholesterine-benzoate).
Staveley, H. E., Bergmann, W., J. Org. Chem., 1, 567, 575 (1936). See also, Eck, J. C., van Peursem, R. L., Hollingsworth, E. W., J. Amer. Chem. Soc., 61, 171 (1939).
Butenandt, A., Kudfuss, H., Z. Physiol. Chem., 253, i (1938).
To be published in Acta Internat. Contra Cancrum.
Bergman, E., Hirsberg, Y., NATURE, 142, 1037 (1938).
Waterman, N., Acta brevia neerlandica, 9, 143 (1939).
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VELDSTRA, H. Δ 3,5-Cholestadiene from Cholesteryl Oleate and its Possible Bearing upon the Formation of Carcinogenic Substances in Heated Fats. Nature 144, 246–247 (1939). https://doi.org/10.1038/144246a0
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DOI: https://doi.org/10.1038/144246a0
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