IODOACETATE poisoning decreases the rate of absorption of glucose and the ‘actively absorbed’ hexoses from the intestine of rats by about 60 per cent, whereas the absorption of xylose is not affected by this poison1. Adrenalectomy has the same effect on sugar absorption2. According to Meyerhof3, iodoacetate acts on glycolysis by suppression of the oxido-reduction between pyruvic acid and triosephosphate. It has been suggested4 that adrenalectomy influences the glycolytic metabolism in a similar way. Now it has been shown by various American workers that adrenalectomy is followed by a severe disturbance in the excretion and distribution of electrolytes, and that by means of a diet containing no potassium and much sodium it is possible to maintain life with adrenalectomized animals indefinitely. It was therefore tried whether the effect of iodoacetate on sugar absorption also depends on the electrolyte composition.
Wilbrandt, W., and Laszt, L., Biochem. Z., 259, 398 (1933).
Wilbrandt, W., and Lengyel, L., Biochem. Z., 267, 204 (1933). Laszt, L., and Verzar, F., NATURE, 138, 844 (1936).
Meyerhof, O., Helv. chim. Acta, 18, 1030 (1935).
Laszt, L., and Verzàr, F., Pflügen Arch., 236, 693 (1935).
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LASZT, L. Influence of Sodium Chloride on Glucose Absorption from the Intestine of Iodoacetate-poisoned Rats. Nature 144, 244 (1939). https://doi.org/10.1038/144244b0
The Hexosemonophosphoric Acids Formed within the Intestinal Mucosa During Absorption of Fructose, Glucose and Galactose.1
Acta Physiologica Scandinavica (1942)