Influence of Sodium Chloride on Glucose Absorption from the Intestine of Iodoacetate-poisoned Rats

Abstract

IODOACETATE poisoning decreases the rate of absorption of glucose and the ‘actively absorbed’ hexoses from the intestine of rats by about 60 per cent, whereas the absorption of xylose is not affected by this poison1. Adrenalectomy has the same effect on sugar absorption2. According to Meyerhof3, iodoacetate acts on glycolysis by suppression of the oxido-reduction between pyruvic acid and triosephosphate. It has been suggested4 that adrenalectomy influences the glycolytic metabolism in a similar way. Now it has been shown by various American workers that adrenalectomy is followed by a severe disturbance in the excretion and distribution of electrolytes, and that by means of a diet containing no potassium and much sodium it is possible to maintain life with adrenalectomized animals indefinitely. It was therefore tried whether the effect of iodoacetate on sugar absorption also depends on the electrolyte composition.

References

  1. 1

    Wilbrandt, W., and Laszt, L., Biochem. Z., 259, 398 (1933).

    CAS  Google Scholar 

  2. 2

    Wilbrandt, W., and Lengyel, L., Biochem. Z., 267, 204 (1933). Laszt, L., and Verzar, F., NATURE, 138, 844 (1936).

    CAS  Google Scholar 

  3. 3

    Meyerhof, O., Helv. chim. Acta, 18, 1030 (1935).

    CAS  Article  Google Scholar 

  4. 4

    Laszt, L., and Verzàr, F., Pflügen Arch., 236, 693 (1935).

    Article  Google Scholar 

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LASZT, L. Influence of Sodium Chloride on Glucose Absorption from the Intestine of Iodoacetate-poisoned Rats. Nature 144, 244 (1939). https://doi.org/10.1038/144244b0

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