Abstract
AS has been increasingly emphasized lately, the fundamental problem of protein structure is to explain the existence of very large but chemically and physically well-defined molecules. It is evident that any two-dimensional pattern of amino-acid residues will either be incapable of folding to form a closed cage-like structure, or will form such a structure only in certnin ways which correspond to definite numbers of residues. Irrespective of the particular nature of the characteristic protein fabric, the idea of closed structures (such as n cage2 or torus or surfaces of higher connectivity) has therefore been offered as an explanation of the existence of these protein megamolecules.
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References
Selbert, Pedersea, and Tiselius, J. Exper. Med., 68, 413 (1938).
Wrinch, Cold Spring Harbor Symposium on Proteins, 6 (1938).
Wrinch, Phil. Mag., 26, 313 (1938).
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WRINCH, D. The Tuberculin Protein TBU-Bovine (523). Nature 144, 77 (1939). https://doi.org/10.1038/144077a0
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DOI: https://doi.org/10.1038/144077a0
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