Abstract
WE have for some time been engaged in a study of the ‘filtrate factor’1 using young rats as test animals and following the technique described by Edgar, El-Sadr and Macrca2. The first attempts to purify the material gave evidence that at least two unknown active principles are present in crude preparations of filtrate factor from liver. When the acidified aqueous extract containing the filtrate factor was extracted with ether, a separation was observed. The material from the ether extract gave a definite growth response, which, however, was less pronounced than that obtained with the whole crude filtrate factor, even if large doses were administered. On the other hand, the material from the aqueous layer after complete extraction with ether also produced a definite increase of growth. The combination of both parts gave a greater effect, similar to that obtained with the original material.
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References
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HOFFER, M., REICHSTEIN, T. Activity of β-Alanine in Stimulating Growth of Young Rats on a Diet Deficient in ‘Filtrate Factor'. Nature 144, 72–73 (1939). https://doi.org/10.1038/144072b0
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DOI: https://doi.org/10.1038/144072b0
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