Abstract
THE only reliable method for determination of the saturation of the living body by vitamin C has so far been that of Tillmann-Harris-Ray. It consists essentially of the daily administration of 300 mgm. of ascorbic acid intravenously, until at least half of this amount reappears in the urine. If the body was saturated, the ejection of this quantity takes place within 1–4 days afterwards. If hypovitaminosis dominates, then the ejection is delayed. So far, by examining blood directly only extreme values can be evaluated: above 1 mgm. per cent indicates saturation, while below 0.4 mgm. per cent indicates hypovitaminosis. Concentrations ranging between cannot be evaluated properly, because 0.5 mgm. per cent may already signify saturation, while in contradistinction 0.9 mgm. per cent may, in certain circumstances, indicate hypovitaminosis.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
GÓTH, A. A New Method of the Determination of Saturation by Vitamin C. Nature 143, 557–558 (1939). https://doi.org/10.1038/143557b0
Issue Date:
DOI: https://doi.org/10.1038/143557b0
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.