Abstract
Kaplan and Chaikoff1 have shown that the fatty infiltration of the liver in depancreatized insulin-treated dogs can be inhibited by the addition of raw pancreas to the usual diet. Dragstedt2 and his co-workers then showed that the active factor can be extracted from pancreas by the aid of alcohol. In conjunction with these investigations, we sought to answer the following two questions: (1) whether in normal rats the fat content of the liver can be influenced by a diet of pancreas ; and (2) whether a variation in the fat content of the liver is linked with a variation of the carbohydrate content.
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References
Kaplan, A., and Chaikoff, J. Biol. Chem., 108, 201 (1935); 119, 435 (1937).
Van Prohaska, I., Dragstedt, L. R., and Harms, H. P., Amer. J. Physiol., 118, 122 (1936) ; 117, 166, 175 (1936).
Channon, H. J., and Wilkinson, H., Biochem. J., 30, 1033 (1936).
MacKay, E. M., Amer. J. Physiol., 119, 783 (1937).
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SHAPIRO, B., WERTHEIMER, E. Action of Pancreatic Extract on Fatty Liver. Nature 140, 771 (1937). https://doi.org/10.1038/140771a0
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DOI: https://doi.org/10.1038/140771a0
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