Abstract
I have developed a procedure to simultaneously examine the distribution of multiple neurotransmitter receptor binding sites, in ten different cortical regions of human brain: Normal, Schizophrenia(Sch), Alzheimer's disease(AD) and Multi Infarct Dementia (MID).
Aliquots of membrane suspension from each cortical region were simultaneously assayed, in the absence and presence of cold ligands, for the binding of radiolabeled nicotine, ketanserin and SCH 23390 to nicotine, serotonin 5HT2 and dopamine D1 receptors respectively. Review of Multiple Neurotransmitter Receptor Binding Analysis Data obtained in this study, revealed the following:
- 5HT2 receptor binding in all ten cortical regions showed a significant increase in Sch brains and a remarkabledecrease in AD and MID brains.
- Nicotine receptor binding undergoes significantreduction in all ten cortical regions from AD and MID brains, and in 9 out of 10 cortical regions in Sch brains.
- D1 receptor binding was enhanced in all ten cortical regions in Sch brains.
Findings from this investigation may have important implications in the prevention and treatment of Neurodegenerative diseases.
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Murthy, L. Multiple Neurotransmitter Receptor Analysis in Human Brain: It's Significance in Neurodegenerative Diseases. Neuropsychopharmacol 11, 277 (1994). https://doi.org/10.1038/sj.npp.1380183
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DOI: https://doi.org/10.1038/sj.npp.1380183