Abstract
In a study of the efficacy and safety of remoxipride compared with haloperidol in schizophrenia (DSM 111 R criteria), EEG frequencies were mapped before and after six weeks of medication. To be reported here, EEG changes had to reach statistical significance of t-scores of 3 or more and had to be present in both eyes-closed and eyes-open recordings. Delta (0.5-3.5 Hz) did not change significantly. Theta (4.0-7.5 Hz) decreased in the left anterior temporal, right frontal and right parietal lobes. Alpha (8.0-11.5) decreased in the right anterior temporal, left posterior temporal and right occipital lobes. Beta1 (12.0-15.5 Hz), beta2 (16-19.5 Hz) and beta3 (20.0-23.5 Hz) all decreased in the left posterior temporal lobe. Beta2 and 3 also decreased in the occipital lobes. Morstyn et al (1983) reported that in schizophrenia: (1) slow activity was increased anteriorly; (2) fast activity was increased posteriorly and in the left anterior temporal lobe. A very similar pattern was found in our patients before treatment. Antipsychotic medication returned our patients' EEGs towards normal. © 1994 American College of europsychopharmacology
Article PDF
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Moore, N., Brin, F., Merai, P. et al. Antipsychotic Medication Changes the EEG of Schizophrenic Patients Towards Normal. Neuropsychopharmacol 11, 277 (1994). https://doi.org/10.1038/sj.npp.1380180
Published:
Issue Date:
DOI: https://doi.org/10.1038/sj.npp.1380180