Abstract
BLOOD coagulation, which is a special case of protein denaturation, has been found to be a chain reaction by which a new reacting substance is formed1. By the action of heat on a mono-disperse system of highly purified serum-globulin in a salt solution, a similar reaction was found to take place. The denaturation process was followed by means of nephelometric measurements with a Pulfrich photometer. The denaturation was limited to a time of exposure to heat (waterbath at 70° C.) by which the coagulated denatured particles of proteins are assumed to remain practically of the same size2. It could therefore be assumed that the nephelometric values expressed the real amounts of proteins denaturated.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Fischer, A., NATURE, 135, 1075 (1935).
Clark, J. H., J. Gen. physiol., 19, 199 (1935).
Fischer, A., Biochem. Z., 278, 133 (1935).
Chick, H., and Martin, C. J., J. Physiol., 45, 61 (1913).
Svedberg, T., Kolloid Z., 51, 10 (1930).
Astbury, W., Dickinson, S., and Bailey, K., Biochem. Z., 29, 2351 (1935).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
FISCHER, A. Heat Denaturation of Proteins as a Chain Reaction. Nature 137, 576–577 (1936). https://doi.org/10.1038/137576a0
Issue Date:
DOI: https://doi.org/10.1038/137576a0
This article is cited by
-
Cancro e denaturazione delle proteine
Experientia (1946)
-
Das Problem Der Proteinsynthese im Physiologischen und Pathologischen Leben
Klinische Wochenschrift (1938)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
