Relation between the Toxicities and the Boiling Points of Related Substances

Abstract

IN attempts to relate the toxicity of physiologically active substances to their chemical constitution or physical properties, it has been the custom to use as comparative indexes of toxicity the numerical values of the molar doses or concentrations producing equal physiological effects. It is well known that the degree of physiological response to different doses or concentrations of the same substance, in many cases at least, varies directly as the logarithm of the dose or concentration applied. Hence, when the toxicities of different substances are being compared, it would appear probable that the use of the logarithms of equi-effective molar doses is more likely to yield quantitative relationships between toxicity and, say, physical properties than the simple numerical values.