Abstract
The past decade has seen a complete change in our conception of the etiology of pernicious anaemia: formerly attributed to haemolytic toxins, it is now regarded as a nutritional disorder. In 1926 Minot, Murphy and their co-workers demonstrated that liver was effective in pernicious anaemia1 and that the haemopoietic response was quantitatively related to the amount of material administered2. Following the bone marrow studies of Peabody3, it appeared that a substance contained in liver allowed the maturation of megalo-blasts to normoblasts and thus to adult red blood cells.
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References
G. R. Minot and W. P. Murphy, J. Amer. Med. Assoc., 87, 470–476; 1926.
G. R. Minot, E. J. Cohn, W. P. Murphy and H. A. Lawson, Amer. J. Med. Sci., 175, 599–622; 1928.
F. W. Peabody, Amer. J. Path., 3, 179–202; 1927.
S. Fenwick, ” On Atrophy of the Stomach and on Nervous Affections of the Digestive Organs”. (London: J. and A. Churchill, 1880.)
W. B. Castle and E. A. Locke, J. Clin. Invest., 6, 2–3; 1928.
W. B. Castle, Amer. J. Med. Sci., 178, 748–764; 1929.
W. B. Castle and W. C. Townsend, Amer. J. Med. Sci., 178, 764–777; 1929.
W. B. Castle, W. C. Townsend and C. W. Heath, Amer. J. Med. Sci., 180, 305–335; 1930.
W. B. Castle, C. W. Heath and M. B. Strauss, Amer. J. Med. Sci., 182, 741–764; 1931.
C. C. Ungley and G. V. James, Quart. J. Med., 3, 523–548; 1934.
W. B. Castle, Ann. Int. Med., 7, 1–5; 1933.
K. Singer, Wien. klin. Wchnschr., 45, 1063–1064; 1932.
D. K. Miller and C. P. Rhoads, New Eng. Med. J., 211, 921–924; 1934.
J. Gröen, ” Klinisch en experimented onderzock over anaemia perniciosa en voorwaardelijke deflcientie”. (Amsterdam: Scheltema et Holkema's Bockhandel, 1935.)
F. Reimann, Med. Klin., 27, 880–881; 1931.
P. J. Fouts and L. G. Zerfas, J. Amer. Med Assoc., 101, 188–192; 1933.
M. B. Strauss and W. B. Castle, New Eng. J. Med., 207, 55–59; 1932.
L. Wills, Lancet, 1, 1283–1286; 1933.
L. Wills and A. Naish, Lancet, 1, 1286; 1933.
F. Diehl and J. Kuhnaü, Deutsch. Arch. klin. Med., 176, 149–153; 1933.
H. C. A. Lassen and H. K. Lassen, Amer. Med. Sci., 188, 461–472; 1934.
L. Klein and J. F. Wilkinson, Biochem. J., 28, 1684–1692; 1934.
J. F. Wilkinson, Proc. Roy. Soc. Med., 26; 632–634; 1933.
E. Meulengracht, Proc. Roy. Soc. Med., 28, 841–868; 1935.
W. B. Castle, Science, 82, 159–164; 1935.
E. J. Cohn, T. L. McMeekin and G. R. Minot, Trans. Assoc. of Amer. Physicians, 45, 343–349; 1930.
M. Gänsslen, Klin. Wchnschr., 9, 2099–2102; 1930.
W. B. Castle and F. H. L. Taylor, J. Amer. Med. Assoc., 96, 1198–1201; 1931.
H. D. Dakin and R. West, J. Biol. Chem., 109, 489–522; 1935.
J. Vaughan, Arch. Int. Med., 47, 688–689; 1931.
C. C. Ungley and F. J. Nattrass : to be published.
A. F. Hurst, Brit. Med. J., 2, 665–669; 1934.
C. C. Ungley, Proc. Roy. Soc. Med., 28, 868–870; 1935.
E. Mellanby, Edin. Med. J., 40, 197–222; 1933.
E. F. Gildea, E. E. Kattwinkel and W. B. Castle, New England J. Med., 202, 523–527; 1930.
W. Sargant, Lancet, 1, 230–232; 1932.
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Ungley, C. The Liver Principle Active in Pernicious Anæmia. Nature 137, 210–213 (1936). https://doi.org/10.1038/137210a0
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DOI: https://doi.org/10.1038/137210a0