Abstract
IN previous investigations, the reaction between phenyl isocyanate and proteins has been used to study the immunological properties of protein antigens1. In other investigations2, it was found that insulin is readily inactivated by phenyl- and p-bromo-phenyl isocyanates, and from the information derived from the earlier work, the conclusion was reached that this inactivation is due to a reaction between the isocyanate and the free amino-groups of the insulin. Jensen and Evans simultaneously investigated this inactivation of insulin3, and reached somewhat similar conclusions.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Hopkins, S. J., and Wormall, A., Biochem. J., 27, 740 and 1706; 1933. 28, 228; 1934.
Hopkins S. J., and Wormall, A., NATURE, 134, 290; 1934. Biochem. J., 28, 2125; 1934.
Jensen, H., and Evans, E. A., J. Biol. Chem., 108, 1; 1935. cf. also, Physiol. Rev., 14, 188; 1934.
Bergmann, M., and Zervas, L., Ber., 65, 1192; 1932. cf. Bergmann, NATURE, 131, 662 and 698; 1933.
Jensen, H., Science, 75, 614; 1932.
Freudenberg, K., Dirscherl, W., and Eyer, H., Z. physiol. Chem., 202, 128; 1931.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
GAUNT, W., HIGGINS, G. & WORMALL, A. Action of Benzylcarbonyl Chloride on Insulin and Other Proteins. Nature 136, 438–439 (1935). https://doi.org/10.1038/136438a0
Issue Date:
DOI: https://doi.org/10.1038/136438a0
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
