Letter | Published:

Effect of 2:6-Dichlorophenol-Indophenol on Tumour and Kidney Respiration

Naturevolume 134page254 (1934) | Download Citation



IT has recently been shown1 that 2: 6 dichlorophenol-indophenol, among other oxidising agents, inhibits reversibly glycolysis in muscle extract. It was of interest, therefore, to try the effect of this substance on tumour tissue. Though inhibition of glycolysis was not found, the effects on respiration were striking. The experiments were carried out with the Dixon-Keilin apparatus2 and the concentration of dichlorophenol-indophenol in the bicarbonate-containing medium was 1.3 × 103 M.

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  1. 1

    Lipmann, Biochem. Z., 265, 133 ; 1933.

  2. 2

    Biochem. J., 27, 86 ; 1933.

  3. 3

    Waldschmidt-Leitz, McDonald, et al., Z. Physiol. Chem., 219, 115 ; 1933.

  4. 4

    Harris, NATURE, 132, 27, July 1, 1933.

  5. 5

    Harris, NATURE, 132, 605, Oct. 14, 1933.

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  1. Cancer Research Laboratories, Graduate School of Medicine, University of Pennsylvania, Philadelphia, Pa.

    • K. A. C. ELLIOTT


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