IN his presidential address to the Royal Microscopical Society delivered on Jan. 20, Prof. R. Ruggles Gates reviewed present knowledge regarding nuclear structure, especially in relation to genetics. On the basis partly of investigations in his own laboratory, Prof. Gates believes that the nucleolus contains two substances, one of which enters the chromosomes in prophase and leaves them in the telphase of mitosis, and that the chromosome is a double structure throughout the mitotic cycle, a split of the chromonema occurring in metaphase for separation in the following metaphase. The chromonema is derived by the union of chromosomes in prophase, and during interkinesis the chromosome is represented by a double chain of chromomeres. From the evidence of karyomeres in animal cells, the nucleus is regarded as a compound structure, and it was further suggested that the spindle is also compound, the real unit in mitosis being a chromosome with its surrounding karyolymph, which becomes transformed into spindle fibres.
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Structure of the Cell Nucleus. Nature 129, 161 (1932). https://doi.org/10.1038/129161b0