Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Structure of the Cell Nucleus


IN his presidential address to the Royal Microscopical Society delivered on Jan. 20, Prof. R. Ruggles Gates reviewed present knowledge regarding nuclear structure, especially in relation to genetics. On the basis partly of investigations in his own laboratory, Prof. Gates believes that the nucleolus contains two substances, one of which enters the chromosomes in prophase and leaves them in the telphase of mitosis, and that the chromosome is a double structure throughout the mitotic cycle, a split of the chromonema occurring in metaphase for separation in the following metaphase. The chromonema is derived by the union of chromosomes in prophase, and during interkinesis the chromosome is represented by a double chain of chromomeres. From the evidence of karyomeres in animal cells, the nucleus is regarded as a compound structure, and it was further suggested that the spindle is also compound, the real unit in mitosis being a chromosome with its surrounding karyolymph, which becomes transformed into spindle fibres.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Structure of the Cell Nucleus. Nature 129, 161 (1932).

Download citation

  • Issue Date:

  • DOI:


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing