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  • Original Article
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Ink4c is dispensable for tumor suppression in Myc-induced B-cell lymphomagenesis

Oncogene volume 26, pages 2833–2839 (2007)Cite this article

Abstract

p18Ink4c functions as a dedicated inhibitor of cyclin-D-dependent kinases. Loss of Ink4c predisposes mice to tumor development and, in a dose-dependent manner, complements the tumor-promoting effects of various oncogenes. We have now addressed whether Ink4c loss impacts B-cell tumor development in the Eμ-Myc transgenic mouse, a model of human Burkitt lymphoma. Loss of one or both alleles did not influence the onset of lymphoma in Eμ-Myc transgenics, and did not appreciably affect Myc's proliferative or apoptotic responses in precancerous B cells. Nevertheless, Ink4c loss modulated the effects of Myc-induced transformation by decreasing the frequency of Arf loss, an ordinarily common event in Eμ-Myc-induced lymphomas.

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Acknowledgements

We thank Elsie White, Lottie Peppers, Sara Norton, Sara Rimpi and Rose Mathew for excellent technical assistance. We are also indebted to Mariano Barbacid for providing Ink4c-null mice, Charles Sherr and Frederique Zindy for criticisms on the paper, Olivier Ayrault, Michael Wang and Deanna Naeve with CGH analysis, and the personnel of the Animal Resource Center and Flow Cytometry Core of St Jude Children's Research Hospital. This work was supported in part by NIH Grants NIH CA-71907 (MFR), RO1 CA-76379 (JLC), Cancer Center Support Grant CA-21765, and by the American Lebanese Syrian Associated Charities (ALSAC) of St Jude Children's Research Hospital. The Swedish Cancer Society, Lion's Cancer Research Foundation of Northern Sweden, The Charities of the Medical Faculty of Umeå University and The Kempe Foundation are granting JAN. LMN acknowledges a graduate student scholarship from the JCKempe Memorial Foundation.

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Authors and Affiliations

  1. Department of Biochemistry, St Jude Children's Research Hospital, Memphis, TN, USA

    L M Nilsson, U B Keller, C Yang, J A Nilsson & J L Cleveland

  2. Department of Genetics and Tumor Cell Biology, St Jude Children's Research Hospital, Memphis, TN, USA

    L M Nilsson & M F Roussel

  3. Department of Molecular Biology, Umeå University, Umeå, Sweden

    L M Nilsson & J A Nilsson

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  1. L M Nilsson
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  2. U B Keller
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  4. J A Nilsson
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Correspondence to M F Roussel.

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Supplementary Information accompanies the paper on the Oncogene website (http://www.nature.com/onc).

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Nilsson, L., Keller, U., Yang, C. et al. Ink4c is dispensable for tumor suppression in Myc-induced B-cell lymphomagenesis. Oncogene 26, 2833–2839 (2007). https://doi.org/10.1038/sj.onc.1210104

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