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TGF-β, Neuronal Stem Cells and Glioblastoma

Oncogene volume 24, pages 5722–5730 (2005)Cite this article

Abstract

Transforming growth factor beta (TGF-β) signaling leads to a number of biological end points involving cell growth, differentiation, and morphogenesis. Typically, the cellular effect accompanies an induction of mesodermal cell fate and inhibition of neural cell differentiation. However, during pathological conditions, these defined effects of TGF-β can be reversed; for example, the growth-inhibitory effect is replaced with its tumor promoting ability. A multitude of factors and cross-signaling pathways have been reported to be involved in modulating the dual effects of TGF-β. In this review, we focus on the potential role of TGF-β signal transduction during development of neural progenitor cells and its relation to glioblastoma development from neural stem cells.

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Acknowledgements

We would like to acknowledge Tiffany Blake and Vidhya Murugesan for their help with this article. This work was supported by NIH Grant R01 DK58637 (BM)

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  1. School of Medicine, Laboratory of Developmental Neurobiology, Georgetown University, Medical Dental Building NW, Room 211-213, 3900 Reservoir Road NW, Washington, 20007, DC, USA

    Nady Golestaneh & Bibhuti Mishra

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Golestaneh, N., Mishra, B. TGF-β, Neuronal Stem Cells and Glioblastoma. Oncogene 24, 5722–5730 (2005). https://doi.org/10.1038/sj.onc.1208925

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