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Src in synaptic transmission and plasticity

Oncogene volume 23, pages 8007–8016 (2004)Cite this article

Abstract

In the central nervous system (CNS), Src and other Src family kinases are widely expressed and are abundant in neurons. Src has been implicated in proliferation and differentiation during the development of the CNS. But Src is highly expressed in fully differentiated neurons in the developed CNS, implying additional functions of this kinase. Over the past decade, a large body of evidence has accumulated showing that a main function of Src is to upregulate the activity of N-methyl-D-aspartate (NMDA) receptors and other ion channels. NMDA receptors (NMDARs) are a principal subtype of glutamate receptors, which mediate fast excitatory transmission at most central synapses. In this review, we focus on Src as a regulator of NMDARs and on the role of Src in NMDAR-dependent synaptic plasticity. We also describe recent studies that give insights into the regulation of Src itself at glutamatergic synapses. By upregulating the function of NMDARs, Src gates the production of NMDAR-dependent synaptic potentiation and plasticity. Thus, Src may be critical for processes underlying physiological plasticity, including learning and memory, and pathological plasticity, such as pain and epilepsy.

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Acknowledgements

This work is supported by the Canadian Institutes of Health Research (CIHR). MWS is a member of the CIHR group on ‘The Synapse’ and holds a Canada Research Chair (Tier I) in Neuroplasticity and Pain.

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Authors and Affiliations

  1. Programme in Brain and Behaviour, The Hospital for Sick Children, University of Toronto, Toronto, M5G 1X8, ON, Canada

    Lorraine V Kalia, Jeffrey R Gingrich & Michael W Salter

  2. Institute of Medical Science, University of Toronto, Toronto, 5S 1A8, ON, Canada

    Lorraine V Kalia & Michael W Salter

  3. Department of Physiology, University of Toronto, Toronto, 5S 1A8, ON, Canada

    Jeffrey R Gingrich & Michael W Salter

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  1. Lorraine V Kalia
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Correspondence to Michael W Salter.

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Kalia, L., Gingrich, J. & Salter, M. Src in synaptic transmission and plasticity. Oncogene 23, 8007–8016 (2004). https://doi.org/10.1038/sj.onc.1208158

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