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Epstein–Barr virus oncogenesis and the ubiquitin–proteasome system

Oncogene volume 23, pages 2107–2115 (2004)Cite this article

Abstract

Epstein–Barr virus (EBV), a human herpesvirus associated with lymphoid and epithelial cell tumors, encodes several proteins that exploit the ubiquitin–proteasome system to regulate latency and allow the persistence of infected cells in immunocompetent hosts. Further modifications of ubiquitin-dependent proteolysis by activated cellular oncogenes contribute to malignant transformation. A detailed understanding of these processes may lead to the development of new therapeutic strategies for EBV-associated cancers.

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Acknowledgements

This research was supported by grants from the Swedish Cancer Society, the Swedish Foundation of Strategy Research, the Petrus och Augusta Hedlunds Stiftelsen, and the Karolinska Institute, Stockholm, Sweden.

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    Maria G Masucci

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Masucci, M. Epstein–Barr virus oncogenesis and the ubiquitin–proteasome system. Oncogene 23, 2107–2115 (2004). https://doi.org/10.1038/sj.onc.1207372

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