Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Review
  • Published:

Roles of BRCA1 in centrosome duplication

Oncogene volume 21, pages 6222–6227 (2002)Cite this article

Abstract

Centrosome duplication is under precise control and occurs only once in a normal mammalian cell cycle. Disruption of this process causes centrosome amplification, unequal segregation of chromosomes and, ultimately, tumorigenesis. Recent studies indicate that breast cancer suppressor gene 1 (BRCA1) plays an important role in regulating centrosome duplication. BRCA1 is located in the centrosome and binds to γ-tubulin. It interacts with a variety of proteins that regulate centrosome duplication, including BRCA2, CDK2–Cyclin A, CDK2–Cyclin E, Gadd45, p21, p53 and Rb. Furthermore, targeted disruption of murine BRCA1 results in centrosome amplification, suggesting that BRCA1 serves as a negative regulator for centrosome duplication. This review will examine these data and discuss possible relationships between BRCA1 and its interacting proteins in centrosome duplication.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1
Figure 2
Figure 3

Similar content being viewed by others

References

  • Alberg AJ, Helzlsouer KJ . 1997 Curr. Opin. Oncol. 9: 505–511

  • Alberg AJ, Lam AP, Helzlsouer KJ . 1999 Curr. Opin. Oncol. 11: 435–441

  • Aprelikova O, Pace AJ, Fang B, Koller BH, Liu ET . 2001 J. Biol. Chem. 276: 25647–25650

  • Balczon R, Bao L, Zimmer WE, Brown K, Zinkowski RP, Brinkley BR . 1995 J. Cell. Biol. 130: 105–115

  • Bochar DA, Wang L, Beniya H, Kinev A, Xue Y, Lane WS, Wang W, Kashanchi F, Shiekhattar R . 2000 Cell 102: 257–265

  • Brodie SG, Deng CX . 2001 Trends Genet. 17: S18–S22

  • Brodie SG, Xu X, Qiao W, Li WM, Cao L, Deng CX . 2001 Oncogene 20: 7514–7523

  • Chai YL, Cui J, Shao N, Shyam E, Reddy P, Rao VN . 1999 Oncogene 18: 263–268

  • Chapman MS, Verma IM . 1996 Nature 382: 678–679

  • Deng C, Zhang P, Harper JW, Elledge SJ, Leder P . 1995 Cell 82: 675–684

  • Deng CX . 2001 Mutat. Res. 477: 183–189

  • Deng CX . 2002 Environ. Mol. Mutagen. 39: 171–177

  • Deng CX, Brodie SG . 2000 Bioessays 22: 728–737

  • Fan S, Wang J, Yuan R, Ma Y, Meng Q, Erdos MR, Pestell RG, Yuan F, Auborn KJ, Goldberg ID, Rosen EM . 1999 Science 284: 1354–1356

  • Fan W, Jin S, Tong T, Zhao H, Fan F, Antinore MJ, Rajasekaran B, Wu M, Zhan Q . 2002 J. Biol. Chem. 277: 8061–8067

  • Fukasawa K, Choi T, Kuriyama R, Rulong S, Vande Woude GF . 1996 Science 271: 1744–1747

  • Gowen LC, Avrutskaya AV, Latour AM, Koller BH, Leadon SA . 1998 Science 281: 1009–1012

  • Gowen LC, Johnson BL, Latour AM, Sulik KK, Koller BH . 1996 Nat. Genet. 12: 191–194

  • Hakem R, de la Pompa JL, Sirard C, Mo R, Woo M, Hakem A, Wakeham A, Potter J, Reitmair A, Billia F, Firpo E, Hui CC, Roberts J, Rossant J, Mak TW . 1996 Cell 85: 1009–1023

  • Hall JM, Lee MK, Newman B, Morrow JE, Anderson LA, Huey B, King MC . 1990 Science 250: 1684–1689

  • Harkin DP, Bean JM, Miklos D, Song YH, Truong VB, Englert C, Christians FC, Ellisen LW, Maheswaran S, Oliner JD, Haber DA . 1999 Cell 97: 575–586

  • Hinchcliffe EH, Li C, Thompson EA, Maller JL, Sluder G . 1999 Science 283: 851–854

  • Hinchcliffe EH, Sluder G . 2001 Curr. Biol. 11: R698–R701

  • Hollander MC, Sheikh MS, Bulavin DV, Lundgren K, Augeri-Henmueller L, Shehee R, Molinaro TA, Kim KE, Tolosa E, Ashwell JD, Rosenberg MP, Zhang Q, Fernandez-Salguero PM, Morgan WF, Deng CX, Fornace Jr AJ . 1999 Nat. Genet. 23: 176–184

  • Hsu LC, Doan TP, White RL . 2001 Cancer Res. 61: 7713–7718

  • Hsu LC, White RL . 1998 Proc. Natl. Acad. Sci. USA 95: 12983–12988

  • Hu YF, Hao ZL, Li R . 1999 Genes Dev. 13: 637–642

  • Jin S, Zhao H, Fan F, Blanck P, Fan W, Colchagie AB, Fornace Jr AJ, Zhan Q . 2000 Oncogene 19: 4050–4057

  • Lane TF, Deng C, Elson A, Lyu MS, Kozak CA, Leder P . 1995 Genes Dev. 9: 2712–2722

  • Lange BM . 2002 Curr. Opin. Cell. Biol. 14: 35–43

  • Lingle WL, Barrett SL, Negron VC, D'Assoro AB, Boeneman K, Liu W, Whitehead CM, Reynolds C, Salisbury JL . 2002 Proc. Natl. Acad. Sci. USA 99: 1978–1983

  • Lingle WL, Lutz WH, Ingle JN, Maihle NJ, Salisbury JL . 1998 Proc. Natl. Acad. Sci. USA 95: 2950–2955

  • Liu CY, Flesken-Nikitin A, Li S, Zeng Y, Lee WH . 1996 Genes Dev. 10: 1835–1843

  • Ludwig T, Chapman DL, Papaioannou VE, Efstratiadis A . 1997 Genes Dev. 11: 1226–1241

  • Mantel C, Braun SE, Reid S, Henegariu O, Liu L, Hangoc G, Broxmeyer HE . 1999 Blood 93: 1390–1398

  • Meraldi P, Honda R, Nigg EA . 2002 EMBO J. 21: 483–492

  • Meraldi P, Lukas J, Fry AM, Bartek J, Nigg EA . 1999 Nat. Cell. Biol. 1: 88–93

  • Merrick BA, Zhou W, Martin KJ, Jeyarajah S, Parker CE, Selkirk JK, Tomer KB, Borchers CH . 2001 Biochemistry 40: 4053–4066

  • Miki Y, Swensen J, Shattuck-Eidens D, Futreal PA, Harshman K, Tavtigian S, Liu Q, Cochran C, Bennett LM, Ding W, Bell R, Rosenthal J, Hussey C, Tran T, McClure M, Frye C, Hattier T, Phelps R, Haugen-Strano A, Katcher H, Yakumo K, Gholami Z, Shaffer D, Stone S, Bayer S, Wray C, Bogden R, Dayananth P, Ward J, Tonin P, Narod S, Bristow PK, Norris FN, Helverting L, Morrison P, Rosteck P, Lai M, Barrett JC, Lewis C, Neuhausen S, Cannon-Albright L, Goldgar D, Wiseman R, Kamb A, Scolnick MH . 1994 Science 266: 66–71

  • Moynahan ME, Chiu JW, Koller BH, Jasin M . 1999 Mol. Cell 4: 511–518

  • Pihan GA, Purohit A, Wallace J, Knecht H, Woda B, Quesenberry P, Doxsey SJ . 1998 Cancer Res. 58: 3974–3985

  • Price BD, Hughes-Davies L, Park SJ . 1995 Oncogene 11: 73–80

  • Rieder CL, Faruki S, Khodjakov A . 2001 Trends Cell. Biol. 11: 413–419

  • Ruffner H, Jiang W, Craig AG, Hunter T, Verma IM . 1999 Mol. Cell. Biol. 19: 4843–4854

  • Scully R, Chen J, Plug A, Xiao Y, Weaver D, Feunteun J, Ashley T, Livingston DM . 1997 Cell 88: 265–275

  • Shen SX, Weaver Z, Xu X, Li C, Weinstein W, Guan XY, Ried T, Deng CX . 1998 Oncogene 17: 3115–3124

  • Somasundaram K, Zhang H, Zeng YX, Houvras Y, Peng Y, Wu GS, Licht JD, Weber BL, El-Deiry WS . 1997 Nature 389: 187–190

  • Tarapore P, Fukasawa K . 2000 Cancer Invest. 18: 148–155

  • Tarapore P, Tokuyama Y, Horn HF, Fukasawa K . 2001 Oncogene 20: 6851–6863

  • Venkitaraman AR . 2002 Cell 108: 171–182

  • Winey M . 1996 Curr. Biol. 6: 962–964

  • Winey M . 1999 Curr. Biol. 9: R449–R452

  • Xu X, Qiao W, Linke SP, Cao L, Li WM, Furth PA, Harris CC, Deng CX . 2001 Nat. Genet. 28: 266–271

  • Xu X, Wagner KU, Larson D, Weaver Z, Li C, Ried T, Hennighausen L, Wynshaw-Boris A, Deng CX . 1999a Nat. Genet. 22: 37–43

  • Xu X, Weaver Z, Linke SP, Li C, Gotay J, Wang XW, Harris CC, Ried T, Deng CX . 1999b Mol. Cell. 3: 389–395

  • Yarden RI, Pardo-Reoyo S, Sgagias M, Cowan KH, Brody LC . 2002 Nat. Genet. 30: 285–289

  • Ye Q, Hu YF, Zhong H, Nye AC, Belmont AS, Li R . 2001 J. Cell. Biol. 155: 911–921

  • Zhang H, Somasundaram K, Peng Y, Tian H, Bi D, Weber BL, El-Deiry WS . 1998 Oncogene 16: 1713–1721

  • Zhang W, McClain C, Gau JP, Guo XY, Deisseroth AB . 1994 Cancer Res. 54: 4448–4453

  • Zheng L, Annab LA, Afshari CA, Lee WH, Boyer TG . 2001 Proc. Natl. Acad. Sci. USA 98: 9587–9592

  • Zheng L, Li S, Boyer TG, Lee WH . 2000 Oncogene 19: 6159–6175

  • Zhong Q, Chen CF, Le S, Chen Y, Wang CC, Xiao J, Chen PL, Sharp ZD, Lee WH . 1999 Science 285: 747–750

Download references

Acknowledgements

I thank R Wang, X Wang and S Mackem for critically reading and comments on the manuscript. I am grateful for Drs LC Hsu and RL White for providing images that are used in Figure 2.

Author information

Authors and Affiliations

  1. Genetics of Development and Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 10/9N105, 10 Center Drive, Bethesda, 20892, Maryland, MD, USA

    Chu-Xia Deng

Authors
  1. Chu-Xia Deng
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Chu-Xia Deng.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Deng, CX. Roles of BRCA1 in centrosome duplication. Oncogene 21, 6222–6227 (2002). https://doi.org/10.1038/sj.onc.1205713

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/sj.onc.1205713

Keywords

This article is cited by

Search

Advanced search

Quick links