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The NOD: a signaling module that regulates apoptosis and host defense against pathogens

Oncogene volume 20, pages 6473–6481 (2001)Cite this article

Abstract

Nods, a growing family of proteins containing a nucleotide-binding oligomerization domain (NOD), are involved in the regulation of programmed cell death (PCD) and immune responses. Members of the family include Apaf-1, Ced-4, Nod1, Nod2, and the cytosolic products of plant disease resistance genes. The NOD module is homologous to the ATP-binding cassette (ABC) found in a large number of proteins with diverse biological function. The centrally located NOD promotes activation of effector molecules through self-association and induced proximity of binding partners. The C-terminal domain of Nods serves as a sensor for intracellular ligands, whereas the N-terminal domain mediates binding to dowstream effector molecules and activation of diverse signaling pathways. Thus, Nods activate, through the NOD module, diverse signaling pathways involved in the elimination of cells via PCD and the host defense against pathogens.

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Acknowledgements

The authors thank P Lucas for critical review of the manuscript. This work was supported by grant R01 CA64556-01 from the NIH.

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  1. Department of Pathology and Comprehensive Cancer Center, The University of Michigan Medical School, Ann Arbor, MI 48109, Michigan, USA

    Naohiro Inohara & Gabriel Nuñez

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Inohara, N., Nuñez, G. The NOD: a signaling module that regulates apoptosis and host defense against pathogens. Oncogene 20, 6473–6481 (2001). https://doi.org/10.1038/sj.onc.1204787

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