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Multiple target sites of allelic imbalance on chromosome 17 in Barrett's oesophageal cancer

Oncogene volume 18, pages 987–993 (1999)Cite this article

Abstract

Twelve Barrett's adenocarcinomas have been analysed for the occurrence of allelic imbalance (LOH) on chromosome 17 using 41 microsatellite markers. This study provides evidence for 13 minimal regions of LOH, six on 17p and seven on 17q. Four of these centre in the vicinity of the known tumour suppressor genes (TSGs) TP53 (17p13.1), NF1 (17q11.2), BRCA1 (17q21.1), and a putative TSG (17p13.3). The tumours all displayed relatively small regions of LOH (1 – 10 cM), and in several tumours extensive regions of LOH were detected. One tumour displayed only two very small regions of LOH; 17p11.2 and 17p13.1. The frequency of allelic imbalance has been calculated based on the LOH encompassing only one minimal region, and based on all the LOH observations. By both evaluations the highest LOH frequencies were found for regions II (p53), III (17p13.1 centromeric to p53), IV (17p12), V (17p11.2) and VII (NF1, 17q11.2). Our data supports the existence of multiple TSGs on chromosome 17 and challenges the view that p53 is the sole target of LOH on 17p in Barrett's adenocarcinoma.

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Acknowledgements

This research was supported by the North West Regional Health Authority UK (JG) and the North West Cancer Research Fund UK (JD), Ursula Keyes Trust (KD), Office of Medical Research, Department of Veterans Affairs, USA (SJM).

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Authors and Affiliations

  1. Molecular Genetics and Oncology Group, Clinical Dental Sciences, The University of Liverpool, Liverpool, L69 3BX, UK

    J Dunn, J Garde, K Dolan & J K Field

  2. Department of Surgery, Thameside General Hospital, Fountain Street, Ashton Under-lyne, Greater Manchester, OL6 9RW, UK

    K Dolan

  3. Department of Pathology, The University of Liverpool, Liverpool, L69 3BX, UK

    J R Gosney

  4. Department of Surgery, The University of Liverpool, Liverpool, L69 3BX, UK

    R Sutton

  5. The University of Maryland and Baltimore Veterans Affairs Hospital, Baltimore, 21201, Maryland, USA

    S J Meltzer

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Dunn, J., Garde, J., Dolan, K. et al. Multiple target sites of allelic imbalance on chromosome 17 in Barrett's oesophageal cancer. Oncogene 18, 987–993 (1999). https://doi.org/10.1038/sj.onc.1202371

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