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The Constitution and Synthesis of Thyroxine

    Naturevolume 120page170 (1927) | Download Citation

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    ABOUT a year ago we refered to the, work of Harington on the isolation the active principle of the thyroid gland and the constitution and synthesis of its first degradations product, desiodo-thyroxine (NATURE, July 10, 1926, vol. 118, p. 65). A recent paper by Harington and Barger now completes this important piece of work by proving tho constitution of thyroxine itself and describing a method for its synthesis (C. R. Harington and O. Barger, Biochem. Journ., 1927, vol. 21, p. 169). The formula for the compound, as suggested by the previous work and proved in the present research, shows that it is a tetra-iodo derivative of the p-hydroxyphenyl ether of tyrosine:

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    https://doi.org/10.1038/120170a0

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