Abstract
IN a previous letter to NATURE of March 10 (111, p. 327) we stated that we had obtained from yeast an insulin-like substance which had the effect of lowering the blood sugar of normal animals. Later we described the beneficial effect of this extract on some cases of diabetes mellitus(Brit. Med. Journ. i. p. 711, 1923). We soon found that the activity of the extract from different samples of yeast varied very widely. The results of these experiments will be published at a later date in conjunction with Dr. H. B. Hutchinson. In this connexion it is of interest to note that Collip (Proc. Soc. of Exp. Biol. and Med., 20, p. 321, 1923) reports numerous failures before he succeeded in obtaining an active extract from yeast, and later Funk and Corbitt (Proc. Soc. of Exp. Biol. and Med., 20, p. 422, 1923) have met with similar variability.
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WINTER, L., SMITH, W. Use of Yeast Extracts in Diabetes. Nature 112, 205 (1923). https://doi.org/10.1038/112205a0
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DOI: https://doi.org/10.1038/112205a0
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