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Association of the aldosterone synthase gene C-344T polymorphism with risk factors and survival in a post-myocardial infarction cohort

Journal of Human Hypertension volume 21, pages 256–258 (2007)Cite this article

The TT genotype of the C-344T polymorphism in the 5′ regulatory region of the aldosterone synthase gene (CYP11B2) has been associated with hypertension (HT), cardiac hypertrophy, higher aldosterone levels in plasma and adrenal tissue, and aldosterone metabolites in urine, increased aldosterone to renin ratios and HT. 1 We investigated possible associations of the CYP11B2 C-344T polymorphism with survival and neurohormonal profiles following acute myocardial infarction (MI). Univariate and multivariate analysis demonstrated a positive association of the TT genotype with survival ( P =0.010) and an interaction between antihypertensive treatment and genotype-influenced survival.

Aldosterone production in adrenal tissue is controlled by the regulated transcription of CYP11B2.2 Several CYP11B2 polymorphisms have been investigated, but studies have concentrated on the C-344T polymorphism. The transcription regulatory factor SF-1 binds the CYP11B2 gene promoter region and is affected by the C-344T polymorphism,3 but controversy remains about the significance of this to expression of aldosterone synthase.4

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Author notes

  1. T E Baird and B R Palmer: These authors contributed equally to this work.

Authors and Affiliations

  1. Department of Medicine, Christchurch Cardioendocrine Research Group, Christchurch School of Medicine and Health Sciences, Christchurch, New Zealand

    T E Baird, B R Palmer, C M Frampton, T G Yandle, L Skelton, A M Richards & V A Cameron

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  1. T E Baird
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  2. B R Palmer
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  3. C M Frampton
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  4. T G Yandle
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  5. L Skelton
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  7. V A Cameron
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Correspondence to B R Palmer.

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Baird, T., Palmer, B., Frampton, C. et al. Association of the aldosterone synthase gene C-344T polymorphism with risk factors and survival in a post-myocardial infarction cohort. J Hum Hypertens 21, 256–258 (2007). https://doi.org/10.1038/sj.jhh.1002130

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