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Perturbation of oxidant–antioxidant status in non-obese prehypertensive male subjects

Journal of Human Hypertension volume 21, pages 176–178 (2007)Cite this article

Although there are experimental and clinical evidences regarding oxidant–antioxidant disturbance in hypertension, clinical data supporting the same in prehypertensive subjects is lacking. Prehypertension (PHT) has been recently described as an independent category of blood pressure (BP). According to Joint National Committee – 7 (JNC-7) report, the term PHT includes the individuals whose systolic BP falls in the range 120–139 mm Hg and diastolic BP in 80–89 mm Hg.1 Das et al.2 have reported that PHT is present in about 58.7% of adults in urban India. Even though the cause of PHT remains unclear, previous studies have documented it as a proinflammatory condition and suggested that it is associated with an increased risk of both heart disease and stroke.3, 4 JNC report on hypertension identifies PHT as one of the risk factors for developing hypertension,1 and oxidative stress may be the common denominator in the development of hypertension in potentially high-risk groups.

As in other cardiovascular diseases, a growing number of reports have assigned a critical role for oxidative stress in the pathogenesis of hypertension.5 It has also been reported that at young age, the prevalence of hypertension is higher in men than in women.6 One of the major causes of the rapid increase in hypertensive population in urban areas can be given to globalization. Globalization has accelerated the dietary and lifestyle shifts, particularly in the developing world, where the nutrition transition has taken place at a faster pace, putting these populations at a greater risk of hypertension. As oxidative stress can be modulated by nutritional, genetic and environmental factors, it was deemed pertinent to study the oxidative stress parameters in non-obese prehypertensive subjects. To our knowledge, this is the first study to compare the oxidative stress parameters in prehypertensive subjects against normotensive controls.

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References

  1. Chobanian AV, Bakris GR, Black HF, Cushman WC, Green LA, Izzo Jr JL et al. For the National Heart, Lung and Blood institute Joint National Committee on prevention, detection, evaluation and treatment of high blood pressure; National high Blood Pressure Education program Coordinating Committee: Seventh report of the Joint National Committee on prevention, detection, evaluation and treatment of high blood pressure: the JNC 7 report. J Am Med Assoc 2003; 289: 2560–2572.

    Article  CAS  Google Scholar 

  2. Das SK, Sanyal K, Basu A . Study of urban community survey in India: growing trend of high prevalence of hypertension in a developing country. Int J Med Sci 2005; 2: 70–78.

    Article  Google Scholar 

  3. Chrysohoou C, Pitsavos C, Panagiotakos DB, Skoumas J, Stefanadis C . Association between prehypertension status and inflammatory markers related to atherosclerotic disease: the ATTICA Study. Am J Hypertens 2004; 17: 568–573.

    Article  CAS  Google Scholar 

  4. Greenland KJ, Croft JB, Mensah GA . Prevalence of heart disease and stroke risk factors in persons with prehypertension in the United States 1999–2000. Arch Intern Med 2004; 164: 2113–2118.

    Article  Google Scholar 

  5. Ogita H, Liao J . Endothelial function and oxidative stress. Endothelium 2004; 11: 123–132.

    Article  CAS  Google Scholar 

  6. Kearney MP, Whelton M, Reynolds K, Muntner P, Whelton PK, He J. Global burden of hypertension: analysis of worldwide data. Lancet 2005; 365: 217–223.

    Article  Google Scholar 

  7. Qureshi AI, Suri MF, Kirmani JF, Divani AA, Mohammad Y . Is prehypertension a risk factor for cardiovascular diseases? Stroke 2005; 36: 1859–1863.

    Article  Google Scholar 

  8. Clapp BR, Hingorani AD, Kharbanda RK, Mohamed-Ali V, Stephens JW, Vallance P et al. Inflammation-induced endothelial dysfunction involves reduced nitric oxide bioavailability and increased oxidative stress. Cardiovasc Res 2004; 64: 172–178.

    Article  CAS  Google Scholar 

  9. Bast A, Haenen Guido RMM, Doelman CJA . Oxidants and antioxidants: state of art. Am J Med 1991; 91: 2S–22S.

    Article  CAS  Google Scholar 

Download references

Acknowledgements

This work was supported by grant from Department of Science, Technology and Environment, Pondicherry, India. This work was also financially supported by the Council of Scientific and Industrial Research, New Delhi, India, in the form of Senior Research Fellowship to Ms V Sathiyapriya.

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  1. V Sathiyapriya and H Nandeesha: These authors contributed equally to this study.

Authors and Affiliations

  1. Department of Biochemistry, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry, India

    V Sathiyapriya, H Nandeesha, Z Bobby & N Selvaraj

  2. Department of Physiology, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry, India

    P Pavithran

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  1. V Sathiyapriya
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  2. H Nandeesha
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Correspondence to Z Bobby.

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Sathiyapriya, V., Nandeesha, H., Bobby, Z. et al. Perturbation of oxidant–antioxidant status in non-obese prehypertensive male subjects. J Hum Hypertens 21, 176–178 (2007). https://doi.org/10.1038/sj.jhh.1002121

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