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Association of hypertension with single nucleotide polymorphisms in the quantitative trait locus for abdominal obesity-metabolic syndrome on chromosome 17

Journal of Human Hypertension volume 20, pages 419–425 (2006)Cite this article

Abstract

Genome scan in Chinese revealed an association of blood pressure with the microsatellite marker D17S1303, which lies in a quantitative trait locus for the abdominal obesity-metabolic syndrome (AOMS2) at 17p12 on chromosome 17. We previously reported that D17S1303 was associated with hypertension and obesity. Therefore, we studied 10 single nucleotide polymorphisms (SNP) within 3 kb of D17S1303. One hundred and eighty hypertensive subjects (91 men, 89 women, age 53±12 years) and 180 normotensive matched controls (91 men, 89 women, age 52±11) were genotyped using the Sequenom genotyping platform. Allelic frequencies in these Chinese subjects differed from those reported for Caucasians. Three SNPs (rs11656507, rs1357926, rs852319) were homozygous in our subjects. The genotype frequencies of rs852320, rs852321 and rs852322 did not differ between hypertensive and normotensive subjects. However, there were significant differences for rs1525402 (P=0.048), rs2692343 (P=0.022), rs2692344 (P=0.017) and rs2321313 (P=0.028). A four-locus haplotype comprising G at rs1525402, C at rs2692343, C at rs2692344 and G at rs2321313 was associated with lower systolic blood pressure (P=0.023) and normotension (P=0.048). Our results provide further evidence that there is a gene, as yet unidentified, influencing blood pressure in the vicinity of D17S1303 in a quantitative trait locus for abdominal obesity-metabolic syndrome at 17p12.

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Acknowledgements

Analysis using the Sequenom genotyping system was performed with the help of Dr William Mak, Dr You-Qiang Song and Miss Phoebe Ng of the Genome Research Centre, University of Hong Kong. BMY Cheung received a University of Hong Kong Committee on Research and Conference Grant to study hypertension genes. BMY Cheung is a member of the Institute of Cardiovascular Science and Medicine.

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  1. Department of Medicine and Research Centre of Heart, Brain, Hormone and Healthy Aging, University of Hong Kong, Queen Mary Hospital, Hong Kong

    B M Y Cheung, R Y H Leung, Y B Man, K L Ong, L Y F Wong, C P Lau & K S L Lam

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  1. B M Y Cheung
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Correspondence to B M Y Cheung.

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Cheung, B., Leung, R., Man, Y. et al. Association of hypertension with single nucleotide polymorphisms in the quantitative trait locus for abdominal obesity-metabolic syndrome on chromosome 17. J Hum Hypertens 20, 419–425 (2006). https://doi.org/10.1038/sj.jhh.1002003

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