Abstract
Previous studies have shown that high blood pressure causes chronic inflammation. Hypertensive patients are reported to have high-circulating levels of proinflammatory cytokines such as interleukin-6 (IL-6) and high sensitive C-reactive protein (hs-CRP). The pulsatility index (PI) and resistive index (RI) are used as markers of peripheral vascular resistance. In the present study, we evaluated the relationship between carotid haemodynamics and the proinflammatory cytokines, IL-6 and hs-CRP. In all, 41 patients with essential hypertension participated. The intima-media thickness (IMT), peak systolic velocity (pVs), peak diastolic velocity (pVd) and mean velocity (mV) in the common carotid artery were measured using ultrasound Doppler flow methods, and PI [(pVs−pVd)/mV] and RI [(pVs−pVd)/pVs] were calculated. Serum IL-6 and hs-CRP concentrations were measured by an enzyme-linked immunosorbent assay. IMT was positively correlated with age and pulse pressure. Both PI and RI were positively correlated with pulse pressure, IL-6 and hs-CRP. A multiple regression analysis revealed that PI and RI were independently associated with hs-CRP. These results suggested that carotid haemodynamic parameters such as PI and RI are associated with atherosclerosis and inflammation in hypertensive patients.
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References
Ross R . Atherosclerosis: an inflammatory disease. N Engl J Med 1999; 340: 115–126.
Libby P . Inflammation in atherosclerosis. Nature 2002; 420: 868–874.
Lacy F, O'Connor DT, Schmid-Schonbein GW . Plasma hydrogen peroxide production in hypertensives and normotensive subjects at genetic risk of hypertension. J Hypertens 1998; 16: 291–303.
Chae CU, Lee RT, Rifai N, Ridker PM . Blood pressure and inflammation in apparently healthy men. Hypertension 2002; 38: 399–403.
Bautista LE et al. Is C-reactive protein an independent risk factor for essential hypertension? J Hypertens 2001; 19: 857–861.
Abramson JL, Weintraub WS, Vaccarino V . Association between pulse pressure and C-reactive protein among apparently healthy US adults. Hypertension 2002; 39: 197–202.
Blake GJ, Ridker PM . Novel clinical markers of vascular wall inflammation. Circ Res 2001; 89: 763–771.
Gabay C, Kushner I . Acute-phase proteins and other systemic responses to inflammation. N Engl J Med 1999; 340: 448–454.
Rattazzi M et al. C-reactive protein and interleukin-6 in vascular disease: culprits or passive bystanders? J Hypertens 2003; 21: 1787–1803.
Van Snick J . Interleukin-6 an overview. Annu Rev Immunol 1990; 8: 253–278.
Seino Y et al. Interleukin 6 gene transcripts are expressed in human atherosclerotic lesions. Cytokine 1994; 6: 87–91.
Rus HG, Vlaicu R, Niculescu F . Interleukin-6 and interleukin-8 protein and gene expression in human arterial atherosclerotic wall. Atherosclerosis 1996; 127: 263–271.
Reynolds GD, Vance RP . C-reactive protein immunohistochemical localization in normal and atherosclerotic human aortas. Arch Pathol Lab Med 1987; 111: 265–269.
Hatanaka K et al. Immunohistochemical localization of C-reactive protein-binding sites in human atherosclerotic aortic lesions by a modified streptavidin-biotin-staining method. Pathol Int 1995; 45: 635–641.
Zhang YX, Cliff WJ, Schoefl GI, Higgins G . Coronary C-reactive protein distribution: its relation to development of atherosclerosis. Atherosclerosis 1999; 145: 375–379.
Pignoli P et al. Intimal plus medial thickness of the arterial wall: a direct measurement with ultrasound imaging. Circulation 1986; 74: 1399–1406.
Pignoli P, Longo T . Evaluation of atherosclerosis with B-mode ultrasound imaging. J Nucl Med Allied Sci 1988; 32: 166–173.
Casiglia E, Palatini P, Da Ros S, Pagliara V . Effect of blood pressure and physical activity on carotid artery intima-media thickness in stage 1 hypertensives and controls. Am J Hypertens 2000; 13: 1256–1262.
Takiuchi S et al. Diagnostic value of carotid intima-media thickness and plaque score for predicting target organ damage in patients with essential hypertension. J Hum Hypertens 2004; 18: 17–23.
Frauchiger B et al. Comparison of carotid arterial resistive insices with intima-media thickness as sonographic markers of atherosclerosis. Stroke 2001; 32: 836–841.
Watanabe S, Okura T, Kitami Y, Hiwada K . Carotid hemodynamic alterations in hypertensive patients with insulin resistance. Am J Hypertens 2002; 15: 851–856.
Gosling RG et al. The quantitative analysis of occlusive peripheral arterial disease by a non-intrusive ultrasonic technique. Angiology 1971; 22: 52–55.
Poircelot L . Indications of Doppler's ultrasonography in the study of peripheral vessels. Rev Prat 1975; 25: 4671–4680.
Pontremoli R et al. Increased renal resistive index in patients with essential hypertension: a marker of target organ damage. Nephrol Dial Transplant 1999; 14: 360–365.
Okura T et al. Intrarenal and carotid hemodynamics in patients with essential hypertension. Am J Hypertens 2004; 17: 240–244.
Nakatou T, Nakata K, Nakamura A, Itoshima T . Carotid hemodynamic parameters as risk factors for cerebral infarction in Type 2 diabetic patients. Diabet Med 2004; 21: 223–229.
Ebrahim S et al. Carotid plaque, intima media thickness cardiovascular risk factors, and prevalent cadiovascular disease in men and women. Stroke 1999; 30: 841–850.
Barth JD . An update on carotid ultrasound measurement of intima-media thickness. Am J Cardiol 2002; 89 (suppl): 32B–39B.
Sung KC et al. High sensitivity C-reactive protein as an independent risk factor for essential hypertension. Am J Hypertens 2003; 16: 429–433.
Ridker PM . High-sensitivity C-reactive protein and cardiovascular risk: rationale for screening and primary prevention. Am J Cardiol 2003; 92 (suppl): 17K–122K.
Mendall MA et al. C-reactive protein and its relation to cardiovascular risk factors: a population based cross sectional study. BMJ 1996; 312: 1061–1065.
Rohde LED, Hennekens CH, Ridker PM . Survey of C-reactive protein and cardiovascular risk factors in apparently healthy men. Am J Cardiol 1999; 84: 1018–1022.
Yudkin JS, Kumari M, Humphries SE, Mohamed-Ali V . Inflammation, obesity, stress and coronary heart disease: is interleukin-6 the link? Atherosclerosis 2000; 148: 209–214.
Choi H, Cho DH, Shin HH, Park JB . Association of high sensitivity C-reactive protein with coronary heart disease prediction, but not with carotid atherosclerosis, in patients with hypertension. Circ J 2004; 68: 297–303.
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Manabe, S., Okura, T., Watanabe, S. et al. Association between carotid haemodynamics and inflammation in patients with essential hypertension. J Hum Hypertens 19, 787–791 (2005). https://doi.org/10.1038/sj.jhh.1001898
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DOI: https://doi.org/10.1038/sj.jhh.1001898
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