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Haplotype association analysis of the polymorphisms Arg16Gly and Gln27Glu of the adrenergic β2 receptor in a Swedish hypertensive population

Journal of Human Hypertension volume 19, pages 705–708 (2005)Cite this article

Abstract

The Arg16Gly and the Gln27Glu polymorphisms in the gene for the β2-adrenergic receptor (β2AR) have been linked to an increased risk for cardiovascular disease. The aim of the present study was to evaluate the significance of these haplotypes for development of myocardial infarction (MI) as well as other cardiovascular phenotypes. In a prospective study cohort (CAPPP), 522 hypertensive patients (174 MI and 348 matched controls) were analysed for the Arg16Gly and the Gln27Glu polymorphisms by dynamic allele-specific hybridisation. The haplotype could successfully be determined in 516 patients. Haplotype was not significantly associated with MI. Systolic blood pressure (SBP) was higher in patients with Arg16Gly+Gln27Gln and lower in patients with Arg16Gly+Gln27Glu as compared with the other haplotypes. Haplotype was not associated with body mass index, diastolic blood pressure, cholesterol, LDL, HDL triglycerides or a diagnosis of diabetes mellitus. The present study found no evidence that haplotype for the two most common polymorphisms in the β2AR are associated with development of MI in a Swedish hypertensive population, but haplotype may be associated with SBP.

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Acknowledgements

The study was supported by grants from Sahlgrenska Academy (LUA), the Swedish Foundation for Strategic Research, the Sahlgrenska University Hospital Funds, the Swedish Research Council and the Swedish Society of Medicine. The authors are grateful to Lotta Uggla and Anna-Lena Jirestedt (Department of Clinical Pharmacology, Gothenburg, Sweden) for excellent technical assistance.

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Authors and Affiliations

  1. Department of Clinical Pharmacology, Sahlgrenska University Hospital/Sahlgrenska, Göteborg, Sweden

    S M Wallerstedt, A-L Eriksson, C Ohlsson & T Hedner

  2. Department of Internal Medicine, Sahlgrenska University Hospital/Sahlgrenska, Göteborg, Sweden

    C Ohlsson

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  1. S M Wallerstedt
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  2. A-L Eriksson
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  3. C Ohlsson
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  4. T Hedner
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Correspondence to S M Wallerstedt.

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Wallerstedt, S., Eriksson, AL., Ohlsson, C. et al. Haplotype association analysis of the polymorphisms Arg16Gly and Gln27Glu of the adrenergic β2 receptor in a Swedish hypertensive population. J Hum Hypertens 19, 705–708 (2005). https://doi.org/10.1038/sj.jhh.1001897

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  • DOI: https://doi.org/10.1038/sj.jhh.1001897

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