Abstract
Diabetes and hypertension will become increasingly common as the population becomes older and more obese. Together, they markedly increase cardiovascular and renal damage, placing all diabetic hypertensives at high risk. Fortunately, the appropriate use of lifestyle changes and multiple drugs will always slow and often stop the progression of this damage.
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References
Amri K et al. Adverse effects of hyperglycemia on kidney development in rats Diabetes 1999 48: 2240–2245
Mokdad AH et al. The spread of the obesity epidemic in the United States, 1991–1998 JAMA 1999 282: 1519–1522
Samaras K, Campbell LV . Increasing incidence of type 2 diabetes in the third millennium Diabetes Care 2000 23: 441–442
Willett WC, Dietz WH, Colditz GA . Guidelines for healthy weight N Engl J Med 1999 341: 427–434
Wei M et al. The association between cardiorespiratory fitness and impaired fasting glucose and type 2 diabetes mellitus in men Ann Intern Med 1999 130: 89–96
He J et al. Dietary sodium intake and subsequent risk of cardiovascular disease in overweight adults JAMA 1999 282: 2027–2034
Valmadrid CT et al. Alcohol intake and the risk of coronary heart disease mortality in persons with older-onset diabetes mellitus JAMA 1999 282: 239–246
Hansson L et al. Effects of intensive blood-pressure lowering and low-dose aspirin inpatients with hypertension:ϑprincipal results of the Hypertension Optimal Treatment (HOT) randomised trial Lancet 1998 351: 1755–1762
Gaede P et al. Intensified multifactorial intervention inpatients with type 2 diabetes mellitus and microalbuminuria: the Steno type 2 randomised study Lancet 1999 353: 617–622
Lievre M et al. Efficacy of diuretics and beta-blockers in diabetic hypertensivepatients Diabetes Care 2000 23: B65–B71
UK Prospective Diabetes Study Group. Efficacy of atenolol and captopril in reducing risk of macrovascular and microvascular complications in type 2 diabetes: UKPDS 39 BMJ 1998 317: 713–720
Giordano M et al. Effects of angiotensin-converting enzyme inhibitors, Ca2+ channel antagonists and α-adrenergic blockers on glucose and lipid metabolism in NIDDMpatients with hypertension Diabetes 1995 44: 665–671
Jollis JG et al. Calcium channel blockers and mortality in elderlypatients with myocardial infarction Arch Intern Med 1999 159: 2341–2348
Tuomilehto J et al. Effects of calcium-channel blockade in olderpatients with diabetes and systolic hypertension N Engl J Med 1999 340: 677–684
Fogari R et al. Long-term effects of ramipril and nitrendipine on albuminuria in hypertensivepatients with type II diabetes and impaired renal function J Hum Hypertens 1999 13: 47–53
Mathiesen ER et al. Randomised controlled trial of long term efficacy of captopril on preservation of kidney function in normotensivepatients with insulin dependent diabetes and microalbuminuria BMJ 1999 319: 24–25
Hansson L et al. Effect of angiotensin-converting-enzyme inhibition compared with conventional therapy on cardiovascular morbidity and mortality in hypertension: the Captopril Prevention Project (CAPPP) randomised trial Lancet 1999 353: 611–616
Heart Outcomes Prevention Evaluation (HOPE) Study Investigators. Effects of ramipril on cardiovascular and microvascular outcomes in people with diabetes mellitus: results of the HOPE study and MICRO-HOPE substudy Lancet 2000 355: 246 253–259
Pitt B et al. Randomised trial of losartan versus captopril inpatients over 65 with heart failure (Evaluation of Losartan In The Elderly Study, ELITE) Lancet 1997 349: 747–752
Pitt B et al. Effect of losartan compared with captopril on mortality inpatients with symptomatic heart failure: randomised trial—the Losartan Heart Failure Survival Study ELITE II Lancet 2000 355: 1582–1587
Bakris GL et al. Differential effects of valsartan (V) and lisinopril (L) on potassium (K+) homeostasis in hypertensivepatients with nephropathy Am J Hypertens 1999 12: 36A
Fogari R et al. Adding losartan to lisinopril therapy inpatients with hypertension: assessment by 24-hour ambulatory blood pressure monitoring Curr Ther Res 1999 60: 326
Ritz E, Orth SR . Nephropathy inpatients with type 2 diabetes mellitus N Engl J Med 1999 341: 1127–1132
Bakris GL . Maximizing cardiorenal benefit in the management of hypertension: achieving blood pressure goals J Clin Hypertens 1999 1: 141–147
Kaplan NM . Management of hypertension in patients with type 2 diabetic mellitus: guidelines based on current evidence Ann Intern Med 2001 135: 1079–1083
Chan JCN et al. Long-term effects of angiotensin-converting enzyme inhibition and metabolic control in hypertensive type 2 diabeticpatients Kidney Int 2000 57: 590–600
Velussi M et al. Effects of cilazapril and amlodipine on kidney function in hypertensive NIDDMpatients Diabetes 1996 45: 216–222
Estacio RO et al. The effect of nisoldipine as compared with enalapril on cardiovascular outcomes inpatients with non-insulin-dependent diabetes and hypertension N Engl J Med 1998 338: 645–652
Bakris GL, Weir MR, DeQuattro V, McMahon FG . Effects of an ACE inhibitor/calcium antagonist combination on proteinuria in diabetic nephropathy Kidney Int 1998 54: 1283–1289
Tatti P et al. Outcome results of the fosinopril versus amlodipine cardiovascular events randomized trial (FACET) inpatients with hypertension and NIDDM Diabetes Care 1998 21: 597–603
Hattori Y, Hattori S, Kasai K . Troglitazone upregulates nitric oxide synthesis in vascular smooth muscle cells Hypertension 1999 33: 943–948
Nazzaro P et al. Distinct and combined vascular effects of ACE blockade and HMG-CoA reductase inhibition in hypertensive subjects Hypertension 1999 33: 719–725
Samaras K et al. Effects of postmenopausal hormone replacement therapy on central abdominal fat, glycemic control, lipid metabolism and vascular factors in type 2 diabetes Diabetes Care 1999 22: 1401–1407
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Kaplan, N. Hypertension and diabetes. J Hum Hypertens 16 (Suppl 1), S56–S60 (2002). https://doi.org/10.1038/sj.jhh.1001344
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DOI: https://doi.org/10.1038/sj.jhh.1001344
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