Abstract
The mechanisms responsible for reduced arterial distensibility in renal transplant recipients remain to be evaluated. The present longitudinal study was aimed to evaluate the effect of hypertension on the evolution of vessel wall properties in renal transplant recipients. The mechanical properties of the common carotid artery were determined in 24 normotensive and 24 treated hypertensive renal transplant recipients 6–12 weeks after transplantation. The measurements were repeated after 2 years. Arterial distension was determined by using a multigate pulsed Doppler system, blood pressure (BP) was measured by a mercury sphygmomanometer. BP was 127 ± 3/80 ± 2 mm Hg at entry and 133 ± 3/82 ± 2 mm Hg after 2 years in the normotensive group, 146 ± 4/90 ± 3 mm Hg at entry and 145 ± 3/87 ± 2 mm Hg after 2 years in the hypertensive group (P < 0.01, normotensives vs hypertensives). The distensibility coefficient (DC) decreased significantly after 2 years in the hypertensive group (DC 18.3 ± 1.3 10−3/kPa before, 15.1 ± 1.2 10−3/kPa after 2 years, P < 0.05) whereas no significant change was observed in the normotensive group (dc 19.0 ± 1.4 10−3/kPa before, DC 17.8 ± 1.3 10−3/kPa after 2 years, NS). There was a significant correlation between the change of the distensibility coefficient after 2 years and mean arterial pressure (n = 48, r = 0.42, P < 0.01). the results show that the decrease of arterial distensibility after 2 years is accelerated in hypertensive renal transplant recipients despite effective anti-hypertensive treatment. since bp levels were not different at entry into the study and after 2 years, differences in distending pressure along cannot explain the more pronounced decrease of arterial distensibility over time in hypertensive renal transplant recipients.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 digital issues and online access to articles
$119.00 per year
only $9.92 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Barenbrock, M., Hausberg, M., Kosch, M. et al. A longitudinal study of vessel wall properties in normotensive and hypertensive renal transplant recipients. J Hum Hypertens 12, 707–711 (1998). https://doi.org/10.1038/sj.jhh.1000692
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1038/sj.jhh.1000692
Keywords
This article is cited by
-
Aortic stiffness, kidney disease, and renal transplantation
Current Hypertension Reports (2009)