Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Short Communication
  • Published:

Correlation of a T45S variant of apolipoprotein C1 with elevated BMI in persons of American Indian and Mexican ancestries

International Journal of Obesity volume 31, pages 1334–1336 (2007)Cite this article

Abstract

Obesity and diabetes are serious health problems for Americans and especially for those with American Indian or Mexican ancestry. A preliminary survey by protein analysis rather than classical nucleic acid sequencing methods has suggested a correlation between a newly discovered T45S variant of apolipoprotein C1 (ApoC1), found only in persons with American Indian or Mexican ancestry, and elevated body mass index (BMI). American Indians with the S45 ApoC1 variant (n=36) had an average of 9% higher BMI than those who had only T45 ApoC1 (n=192, P=0.029). Elevated rates of diabetes were reported for parents of subjects with the S45 protein (P=0.006). In five gender-matched sibling pairs, persons with Mexican ancestry showed a 1.34-fold higher BMI for those with S45 ApoC1 (P=0.022). This protein may contribute to the elevated rates of diabetes in relevant ethnic groups and might be more common in isolated populations.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1

Similar content being viewed by others

References

  1. Conde-Knape K, Bensadoun A, Sobel JH, Cohn JS, Shachter NS . Overexpression of apoC-I in apoE-null mice: severe hypertriglyceridemia due to inhibition of hepatic lipase. J Lipid Res (2002); 43: 2136–2145.

    Article  CAS  Google Scholar 

  2. Berbee JF, van der Hoogt CC, Sundararaman D, Havekes LM, Rensen PC . Severe hypertriglyceridemia in human APOC1 transgenic mice is caused by apoC-I-induced inhibition of LPL. J Lipid Res (2005); 46: 297–306.

    Article  CAS  Google Scholar 

  3. Poensgen J . Apolipoprotein C-1 inhibits the hydrolysis by phospholipase A2 of phospholipids in liposomes and cell membranes. Biochim Biophys Acta (1990); 1042: 188–192.

    Article  CAS  Google Scholar 

  4. Gautier T, Masson D, de Barros JP, Athias A, Gambert P, Aunis D et al. Human apolipoprotein C-I accounts for the ability of plasma high density lipoproteins to inhibit the cholesteryl ester transfer protein activity. J Biol Chem (2000); 275: 37504–37509.

    Article  CAS  Google Scholar 

  5. Kushwaha RS, Hasan SQ, McGill Jr HC, Getz GS, Dunham RG, Kanda P . Characterization of cholesteryl ester transfer protein inhibitor from plasma of baboons (Papio sp.). J Lipid Res (1993); 34: 1285–1297.

    CAS  PubMed  Google Scholar 

  6. Weisgraber KH, Mahley RW, Kowal RC, Herz J, Goldstein JL, Brown MS . Apolipoprotein C-I modulates the interaction of apolipoprotein E with beta-migrating very low density lipoproteins (beta-VLDL) and inhibits binding of beta-VLDL to low density lipoprotein receptor-related protein. J Biol Chem (1990); 265: 22453–22459.

    CAS  PubMed  Google Scholar 

  7. Liu M, Subbaiah PV . Activation of plasma lysolecithin acyltransferase reaction by apolipoproteins A-I, C-I and E. Biochim Biophys Acta (1993); 1168: 144–152.

    Article  CAS  Google Scholar 

  8. Cohn JS, Tremblay M, Boulet L, Jacques H, Davignon J, Roy M et al. Plasma concentration and lipoprotein distribution of ApoC-I is dependent on ApoE genotype rather than the Hpa I ApoC-I promoter polymorphism. Atherosclerosis (2003); 169: 63–70.

    Article  CAS  Google Scholar 

  9. Shachter NS, Rabinowitz D, Stohl S, Conde-Knape K, Cohn JS, Deckelbaum RJ et al. The common insertional polymorphism in the APOC1 promoter is associated with serum apolipoprotein C-I levels in Hispanic children. Atherosclerosis (2005); 179: 387–393.

    Article  CAS  Google Scholar 

  10. Gao L, Gabriel C, Lavoie T, Ye SQ . An improved RSP method to detect HpaI polymorphism in the apolipoprotein C-1 gene promoter. BMC Med Genet (2002); 3: 13.

    Article  Google Scholar 

  11. Shi J, Zhang S, Ma C, Liu X, Li T, Tang M et al. Association between apolipoprotein CI HpaI polymorphism and sporadic Alzheimer's disease in Chinese. Acta Neurol Scand (2004); 109: 140–145.

    Article  CAS  Google Scholar 

  12. Retz W, Thome J, Durany N, Harsanyi A, Retz-Junginger P, Kornhuber J et al. Potential genetic markers of sporadic Alzheimer's dementia. Psychiatr Genet (2001); 11: 115–122.

    Article  CAS  Google Scholar 

  13. Muurling M, van den Hoek AM, Mensink RP, Pijl H, Romijn JA, Havekes LM et al. Overexpression of APOC1 in obob mice leads to hepatic steatosis and severe hepatic insulin resistance. J Lipid Res (2004); 45: 9–16.

    Article  CAS  Google Scholar 

  14. Wroblewski MS, Wilson-Grady JT, Martinez MB, Kasthuri RS, McMillan KR, Flood-Urdangarin C et al. A functional polymorphism of apolipoprotein C1 detected by mass spectrometry. FEBS J (2006); 273: 4107–4115.

    Article  Google Scholar 

  15. Nelsestuen GL, Zhang Y, Martinez MB, Key NS, Jilma B, Verneris M et al. Plasma protein profiling: unique and stable features of the plasma proteome. Proteomics (2005); 5: 4012–4024.

    Article  CAS  Google Scholar 

Download references

Acknowledgements

This work was supported in part by the endowment to the Samuel Kirkwood professorship (GLN). RSK was supported by a National Hemophilia Clinical Fellowship Award. KM is a Bush Medical Fellow (Bush Foundation). We thank the expert technical assistance of Ms Julia Nguyen and other volunteers who assisted in sample procurement.

Author information

Authors and Affiliations

  1. Department of Medicine, University of Minnesota, Minneapolis, MN, USA

    R S Kasthuri

  2. American Indian Community Development Corporation, Minneapolis, MN, USA

    K R McMillan

  3. St Mary's Health Clinics, St Paul, MN, USA

    C Flood-Urdangarin

  4. Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, USA

    S B Harvey, J T Wilson-Grady & G L Nelsestuen

Authors
  1. R S Kasthuri
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. K R McMillan
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. C Flood-Urdangarin
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. S B Harvey
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. J T Wilson-Grady
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. G L Nelsestuen
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to G L Nelsestuen.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Kasthuri, R., McMillan, K., Flood-Urdangarin, C. et al. Correlation of a T45S variant of apolipoprotein C1 with elevated BMI in persons of American Indian and Mexican ancestries. Int J Obes 31, 1334–1336 (2007). https://doi.org/10.1038/sj.ijo.0803569

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/sj.ijo.0803569

Keywords

This article is cited by

Search

Advanced search

Quick links