Abstract
OBJECTIVE: The aim of this study was to clarify if there is an association between overweight and a state of chronic, low-grade inflammation in adolescents.
DESIGN: The study is a part of the cross-sectional multicenter study AVENA, designed to evaluate the nutritional status of a representative sample of Spanish adolescents. The adolescents were divided into two groups: (1) nonoverweight and (2) overweight/obesity using the International Obesity Task Force (IOTF) standards.
SUBJECTS: A geographically representative subsample of the AVENA study including 493 Spanish adolescents, aged 13–18 y (236 females/257 males), participated in this study.
MEASUREMENTS: Serum C-reactive protein (CRP) and in vitro production of interleukin 6 and tumor necrosis factor α were measured, together with a detailed anthropometry.
RESULTS: The inflammatory markers showed generally higher values in subjects with overweight/obesity than in those with nonoverweight, with only CRP showing significant differences (the means were 0.83 and 1.27 mg/l in the nonoverweight and overweight/obesity groups, respectively).
CONCLUSION: Although we have not studied if adolescent overweight and obesity play an initiating role in the development of future diseases, we suggest it may induce a chronic low-grade inflammatory state, which points out the importance of maintaining an appropriate body weight, to avoid obesity-related diseases in adulthood.
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References
Marti A, Marcos A, Martinez JA . Obesity and immune function relationships. Review. Obes Rev 2001; 2: 131–140.
Chandra RK, Kutty KM . Immunocompetence in obesity. Acta Paediatr Scand 1980; 69: 25–30.
Must A, Strauss RS . Risks and consequences of childhood and adolescent obesity. Int J Obes Relat Metab Disord 1999; 23 (Suppl 2): S2–S11.
Moreno LA, Pineda I, Rodríguez G, Fleta J, Sarría A, Bueno M . Waist circumference for the screening of the metabolic syndrome in children. Acta Paediatr 2002; 91: 1307–1312.
Sonnenberg GE, Krakower GR, Kissebah AH . A novel pathway to the manifestations of metabolic syndrome. Obes Res 2004; 12: 180–186.
Lesauskaite V, Tanganelli P, Bianciardi G, Simoes C, Toti P, Weber G . World Health Organization (WHO) and the World Heart Federation (WHF) Pathobiological Determinants of Atherosclerosis in Youth (PBDAY) Study. Histomorphometric investigation of the aorta and coronary arteries in young people from different geographical locations. Nutr Metab Cardiovasc Dis 1999; 9: 266–276.
McGill Jr HC, McMahan CA, Zieske AW, Sloop GD, Walcott JV, Troxclair DA, Malcom GT, Tracy RE, Oalmann MC, Strong JP . Associations of coronary heart disease risk factors with the intermediate lesion of atherosclerosis in youth. The Pathobiological Determinants of Atherosclerosis in Youth (PDAY) Research Group. Arterioscler Thromb Vasc Biol 2000; 20: 1998–2004.
McGill Jr HC, McMahan CA, Herderick EE, Malcom GT, Tracy RE, Strong JP . Origin of atherosclerosis in childhood and adolescence. Review. Am J Clin Nutr 2000; 72 (Suppl): S1307–S1315.
Millonig G, Malcom GT, Wick G . Early inflammatory-immunological lesions in juvenile atherosclerosis from the Pathobiological Determinants of Atherosclerosis in Youth (PDAY) study. Atherosclerosis 2002; 160: 441–448.
González-Gross M, Castillo MJ, Moreno L, Nova E, González-Lamuño D, Pérez-Llamas F, Gutiérrez A, Garaulet M, Joyanes M, Leyva A, Marcos A, and Grupo AVENA. Alimentación y Valoración del Estado Nutricional de los Adolescentes Españoles (AVENA project). Risk evaluation and intervention proposals. I. Methodological description of the study. Nutr Hosp 2003; 18: 15–28.
Moreno LA, Joyanes M, Mesana MI, González-Gross M, Gil CM, Sarría A, Gutiérrez A, Garaulet M, Pérez-Prieto R, Bueno M, Marcos A, for the AVENA Study Group. Harmonization of anthropometric measurements for a multicenter nutrition survey in Spanish adolescents. Nutrition 2003; 19: 481–486.
Cole TJ, Bellizzi MC, Flegal M, Dietz WH . Establishing a standard definition for child overweight and obesity worldwide: international survey. BMJ 2002; 320: 1–6.
Tanner JM, Whitehouse RH . Clinical longitudinal standards for height, weight, height velocity and stages of puberty. Arch Dis Child 1976; 51: 170–179.
Moreno LA, Tomás C, González-Gross M, Bueno G, Pérez-González JM, Bueno M . Micro-environmental and socio-demographic determinants of childhood obesity. Int J Obes Relat Metab Disord 2004; 28 (Suppl): S16–S20.
Wu DM, Chu NF, Shen MH, Chang JB . Plasma C-reactive protein levels and their relationship to anthropometric and lipid characteristics among children. J Clin Epidemiol 2003; 56: 94–100.
Visser M, Bouter LM, McQuillan GM, Wener MH, Harris TB . Low-grade systemic inflammation in overweight children. Pediatrics 2001; 107: E13 1–6.
Cook DG, Mendall MA, Whincup PH, Carey IM, Ballam L, Morris JE, Miller GJ, Strachan DP . C-reactive protein concentration in children: relationship to adiposity and other cardiovascular disease risk factors. Atherosclerosis 2000; 49: 139–150.
Ford ES, Galuska DA, Gillespie C, Will JC, Giles WH, Dietz WH . C-reactive protein and body mass index in children: findings from the Third National Health and Nutrition Examination Survey, 1988–1994. J Pediatr 2001; 138: 486–492.
Ford ES . Body mass index, diabetes, and C-reactive protein among US adults. Diabetes Care 1999; 22: 1971–1977.
Ziccardi P, Nappo F, Giugliano G, Esposito K, Marfella R, Cioffi M, D'Andrea F, Molinari AM, Giugliano D . Reduction of inflammatory cytokine concentrations and improvement of endothelial functions in obese women after weight loss over one year. Circulation 2002; 105: 804–809.
Marfella R, Esposito K, Siniscalchi M, Cacciapuoti F, Giugliano F, Labriola D, Ciotola M, Di Palo C, Misso L, Giugliano D . Effect of weight loss on cardiac synchronization and proinflammatory cytokines in premenopausal obese women. Diabetes Care 2004; 27: 47–52.
Dixon D, Goldberg R, Schneiderman N, Delamater A . Gender differences in TNF-alpha levels among obese vs nonobese Latino children. Eur J Clin Nutr 2004; 58: 696–699.
Jarvisalo MJ, Harmoinen A, Hakanen M, Paakkunainen U, Viikari J, Hartiala J, Lehtimaki T, Simell O, Raitakari OT . Elevated serum C-reactive protein levels and early arterial changes in healthy children. Atheroscler Thromb Vasc Biol 2002; 22: 1323–1328.
Acknowledgements
This study was supported by the Spanish Ministry of Health (FIS 00/0015) and grants by Panrico, SA, Madaus, SA and Procter & Gamble, SA, España. We gratefully acknowledge all participating adolescents, and their parents and teachers for their collaboration. We also acknowledge Ms Laura Barrios for her statistically support.
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Appendix A1. AVENA Sudy Group
Appendix A1. AVENA Sudy Group
Coordinador:A Marcos, Madrid.
Main Investigators:MJ Castillo, Granada.A Marcos, Madrid.S Zamora, Murcia.M García Fuentes, Santander.M Bueno, Zaragoza, Spain.
Granada: MJ Castillo, MD Cano, R Sola (Biochemistry); A Gutiérrez, JL Mesa, J Ruiz (Physical fitness); M Delgado, P Tercedor, P Chillón (Physical activity), M Martín, F Carreño, F Ortega, GV Rodríguez, R Castillo, F Arellano (Collaborators). Universidad de Granada, E-18071 Granada.
Madrid: A Marcos, M González-Gross, J Wärnberg, S Medina, F Sánchez Muniz, E Nova, A Montero, B de la Rosa, S Gómez, S Samartín, J Romeo, R Álvarez, (Coordination, immunology) A Álvarez (Cytometric analysis) L Barrios (Statistical analysis) A Leyva, B Payá (Psychological assessment). L Martínez, E Ramos, R Ortiz, A Urzanqui (Collaborators). Instituto de Nutrición y Bromatología, Consejo Superior de Investigaciones Científicas (CSIC), E-28040 Madrid.
Murcia: S Zamora, M Garaulet, F Pérez-Llamas, JC Baraza, JF Marín, F Pérez de Heredia, MA Fernández, C González, R García, C Torralba, E Donat, E Morales, MD García, JA Martínez, JJ Hernández, A Asensio, FJ Plaza, MJ López (Diet analysis). Dpto. Fisiología, Universidad de Murcia, E-30100 Murcia.
Santander: M García Fuentes, D González-Lamuño, P de Rufino, R Pérez-Prieto, D Fernández, T Amigo (Genetic study). Dpto. Pediatría, Universidad de Cantabria, E-19003 Santander.
Z aragoza: M Bueno, L Moreno, A Sarriá, J Fleta, G Rodríguez, CM Gil, MI Mesana, JA Casajús, Vicente Blay, María Guadalupe Blay (Anthropometric assessment). Escuela Universitaria de Ciencias de la Salud, Universidad de Zaragoza, E-50009 Zaragoza.
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Wärnberg, J., Moreno, L., Mesana, M. et al. Inflammatory mediators in overweight and obese Spanish adolescents. The AVENA Study. Int J Obes 28 (Suppl 3), S59–S63 (2004). https://doi.org/10.1038/sj.ijo.0802809
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DOI: https://doi.org/10.1038/sj.ijo.0802809
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