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Effect of long-term body weight change on the incidence of hypertension in Japanese men and women

International Journal of Obesity volume 28, pages 391–395 (2004)Cite this article

Abstract

OBJECTIVE: To elucidate the effect of long-term body weight changes on the subsequent incidence of hypertension in a large sample of community-residing Japanese males and females.

METHODS: Subjects were 3431 men and 2409 women, between 30 and 69?y old, who underwent annual periodic health examinations from 1987 (baseline year) until 1996. They were free from hypertension during the first 5?y from the baseline year. Body weight change index between 1987 and 1992 was the body mass index (BMI) (weight (kg) over height (m) squared) slope. Multiple logistic analysis was performed to assess the effect of BMI slope on the incidence of hypertension during the subsequent 5?ys (1992–1996), while controlling for baseline age, BMI, systolic blood pressure (SBP), diastolic blood pressure (DBP) and smoking habit.

RESULTS: During the first 5?y, the prevalence of overweight males (25.0≤BMI<30.0) significantly increased from 18.4 to 23.5% in males and from 10.4 to 14.1% in females. In all, 11.7% of the males and 8.9% of the females developed hypertension between 1992 and 1996. Those who developed hypertension had a significantly higher baseline age, BMI, SBP and DBP both in males and females. The baseline smoking rate among the females who developed hypertension was significantly lower than those who did not develop the hypertension. After adjustment of these covariables by the multiple logistic analysis, the BMI slope was positively correlated with the incidence of hypertension both in females and males significantly.

CONCLUSIONS: Weight gain increased the risk of developing hypertension independent of age and blood pressure level among relatively lean Japanese men and women.

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References

  1. Macmahon S, Peto R, Cutler J, Collins R, Sorlie P, Neaton J, Abbott R, Godwin J, Dyer A, Stamler J . Blood pressure, stroke, and coronary heart disease: prolonged differences in blood pressure: prospective observational studies corrected for the regression dilution bias. Lancet 1990; 335: 765–774.

    Article  CAS  Google Scholar 

  2. Klag MJ, Whelton PK, Randall BL, Neaton JD, Brancati FL, Ford CE, Shulman NB, Stamler J . Blood pressure and end-stage renal disease in men. N Engl J Med 1996; 334: 13–18.

    Article  CAS  Google Scholar 

  3. Kannel WB . The Framingham study: ITS 50-years legacy and future promise. J Atheroscler Thromb 2000; 6: 60–66.

    Article  CAS  Google Scholar 

  4. Ueshima H, Zhang XH, Choudhury SR . Epidemiology of hypertension in China and Japan. J Hum Hypertens 2000; 14: 765–769.

    Article  CAS  Google Scholar 

  5. Staessen JA, Wang JG, Thijs L . Cardiovascular protection and blood pressure reduction: a meta-analysis. Lancet 2001; 358: 1305–1315.

    Article  CAS  Google Scholar 

  6. Must A, Spadano J, Coakley EH, Field AE, Colditz G, Dietz WH . The disease burden associated with overweight and obesity. JAMA 1999; 282: 1523–1529.

    Article  CAS  Google Scholar 

  7. Brown CD, Higgins M, Donato KA, Rohde FC, Garrison R, Obarzanek E, Ernst ND, Horan M . Body mass index and the prevalence of hypertension and dyslipidemia. Obes Res 2000; 8: 605–619.

    Article  CAS  Google Scholar 

  8. Yong LC, Kuller LH, Rutan G, Bunker C . Longitudinal study of blood pressure: changes and determinants from adolescence to middle age. The Dormont High School follow-up study, 1957–1963 to 1989–1990. Am J Epidemiol 1993; 138: 973–983.

    Article  CAS  Google Scholar 

  9. Cassano PA, Segal MR, Vokonas PS, Weiss ST . Body fat distribution, blood pressure, and hypertension. A prospective cohort study of men in the Normative Aging Study. Ann Epidemiol 1990; 1: 33–48.

    Article  CAS  Google Scholar 

  10. Trials of Hypertension Prevention Collaborative Research Group. The effects of nonpharmacologic interventions on blood pressure of persons with high normal levels: results of the Trials of Hypertension Prevention, Phase 1. JAMA 1992; 267: 1213–1220.

  11. Stevens VJ, Corrigan SA, Obarzanek E, Bernauer E, Cook NR, Hebert P, Mattfeldt-Beman M, Oberman A, Sugars C, Dacin AT . Weight loss intervention in phase 1 of the trials of hypertension prevention. The TOHP Collaborative Research Group. Arch Intern Med 1993; 153: 849–858.

    Article  CAS  Google Scholar 

  12. Stevens VJ, Obarzanek E, Cook NR, Appel LJ, West DS, Milas NC, Mattfeldt-Beman M, Belden L, Bragg C, Millstone M, Raczynski J, Brewer A, Singh B, Cohen J . Long-term weight loss and changes in blood pressure: results of the trials of hypertension prevention, phase II. Ann Intern Med 2001; 134: 1–11.

    Article  CAS  Google Scholar 

  13. Ministry of Health, Labour and welfare. National Health and Nutrition Survey. Daiichi: Tokyo; 2001.

  14. Halimi JM, Giraudeau B, Vol S, Caces E, Nivet H, Tichet J . The risk of hypertension in men: direct and indirect effects of chronic smoking. J Hypertension 2002; 20: 187–193.

    Article  CAS  Google Scholar 

  15. Cragg JG, Uhler R . The demand for automobiles. Can J Econ 1970; 3: 386–406.

    Article  Google Scholar 

  16. Kotchen JM, McKean HE, Kotchen TA . Blood pressure trends with aging. Hypertension 1982; 4: III128–III134.

    Article  CAS  Google Scholar 

  17. Lakatta EG . Arterial pressure and aging. Int J Cardiol 1989; 25 (Suppl 1): S81–S89.

    Article  Google Scholar 

  18. He J, Klag MJ, Appel LJ, Charleston J, Whelton PK . Seven-year incidence of hypertension in a cohort of middle-aged African Americans and Whites. Hypertension 1998; 31: 1130–1135.

    Article  CAS  Google Scholar 

  19. Huang Z, Willet WC, Manson JE, Rosner B, Stampher MJ, Speizer FE, Colditz GA . Body weight, weight change, and risk for hypertension in women. Ann Intern Med 1998; 128: 81–88.

    Article  CAS  Google Scholar 

  20. Reed D, McGee D, Yano K . Biological and social correlates of blood pressure among Japanese men in Hawaii. Hypertension 1982; 4: 406–414.

    Article  CAS  Google Scholar 

  21. Wilsgaard T, Schirmer H, Arnesen E . Impact of body weight on blood pressure with focus on sex differences: the Troms Study, 1986–1995. Arch Intern Med 2000; 160: 2847–2853.

    Article  CAS  Google Scholar 

  22. Kushiro T, Kobayashi F, Osada H, Tomiyama H, Satoh K, Otsuka Y, Kurumatani H, Kajiwara N . Role of sympathetic activity in blood pressure reduction with low calorie regimen. Hypertesnion 1991; 17: 965–968.

    Article  CAS  Google Scholar 

  23. Masuo K, Mikami H, Ogihara T, Tuck ML . Weight gain-induced blood pressure elevation. Hypertension 2000; 35: 1135–1140.

    Article  CAS  Google Scholar 

  24. NCHS. Healthy weight, overweight, and obesity among persons 20 years of age and over, according to sex, age, race, and Hispanic origin: United States, 1960–62, 1971–74, 1976–80, 1988–94, and 1999–2000. Health United States 2002. table 70. http://www.cdc.gov/nchs/data/hus/tables/2002/02hus070.pdf.

  25. Okubo Y, Miyamoto T, Suwazono Y, Kobayashi E, Nogawa K . An association between smoking habits and blood pressure in normotensive Japanese men. J Hum Hypertens 2002; 16: 91–96.

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Health Promotion Sciences, Graduate School of Medicine, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo, Japan

    J S Lee & K Mori

  2. Department of Food Sciences and Nutrition, Kyoritsu Women’s University, Hitotubashi, Chiyoda-ku, Tokyo, Japan

    K Kawakubo

  3. PL Tokyo Health Care Center, Kamiyama-tyo, Shibuya-ku, Tokyo, Japan

    H Kashihara

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  1. J S Lee
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Correspondence to J S Lee.

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Lee, J., Kawakubo, K., Kashihara, H. et al. Effect of long-term body weight change on the incidence of hypertension in Japanese men and women. Int J Obes 28, 391–395 (2004). https://doi.org/10.1038/sj.ijo.0802568

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