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The effects of 2-week ingestion of (−)-hydroxycitrate and (−)-hydroxycitrate combined with medium-chain triglycerides on satiety, fat oxidation, energy expenditure and body weight

International Journal of Obesity volume 25, pages 1087–1094 (2001)Cite this article

Abstract

OBJECTIVE: Assessment of the effect of 2-week supplementation with (−)-hydroxycitrate (HCA) and HCA combined with medium-chain triglycerides (MCT) on satiety, fat oxidation, energy expenditure (EE) and body weight (BW) loss.

DESIGN: Three intervention periods of 2 weeks separated by washout periods of 4 weeks. Double-blind, placebo-controlled, randomised and cross-over design.

SUBJECTS: Eleven overweight male subjects (mean±s.d.; age, 47±16 y; body mass index, 27.4 ± 8.2 kg/m2).

INTERVENTION: Subjects consumed three self-selected meals and four iso-energetic (420 kJ) snacks daily with either no supplementation (PLA), 500 mg HCA (HCA) or 500 mg HCA and 3 g MCT (HCA+MCT). Each intervention ended with a 36 h stay in the respiration chamber.

RESULTS: There was a significant BW loss during the 2 weeks of intervention (PLA, −1.0 ± 0.4 kg, P<0.05; HCA, −1.5 ± 0.5 kg, P<0.01; HCA+MCT, −1.3 ± 0.2 kg, P<0.001), but this reduction was not different between treatments. 24 h EE (PLA, 11.8 ± 0.2 MJ; HCA, 11.7 ± 0.1 MJ; HCA+MCT, 11.5 ± 0.1 MJ), 24 h RQ (0.85 ± 0.00 in all treatments) and the area under the curve of the appetite-related parameters were not different between treatments.

CONCLUSION: Two-week supplementation with HCA and HCA combined with MCT did not result in increased satiety, fat oxidation, 24 h EE or BW loss compared to PLA, in subjects losing BW.

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Acknowledgements

We gratefully acknowledge Miranda de Vries, Joan Senden, and Paul Schoffelen for their assistance. This study was supported by Novartis Consumer Health Ltd, Nyon, Switzerland.

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  1. Department of Human Biology, Maastricht University, Maastricht, The Netherlands

    EMR Kovacs, MS Westerterp-Plantenga & WHM Saris

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Correspondence to EMR Kovacs.

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Kovacs, E., Westerterp-Plantenga, M. & Saris, W. The effects of 2-week ingestion of (−)-hydroxycitrate and (−)-hydroxycitrate combined with medium-chain triglycerides on satiety, fat oxidation, energy expenditure and body weight. Int J Obes 25, 1087–1094 (2001). https://doi.org/10.1038/sj.ijo.0801605

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