Abstract
OBJECTIVE: Studies, comparing several disease-prone and disease-resistant rat strains to elucidate the extent and severity of syndromes resembling human diseases are lacking. Therefore we studied the inbred rat strains BB/OK, BN/Crl, LEW/K and WKY/Crl in comparison with SHR/Mol and WOKW/K rats as models of metabolic syndrome.
DESIGN: Body weight and body mass index (BMI) were measured in 12 males of each strain at 14 weeks. In addition blood glucose, serum triglycerides, cholesterol, insulin and leptin were determined at 12, 13 and 14 weeks of age.
RESULTS: In contrast to SHR animals, WOKW rats develop a severe metabolic syndrome including obesity, hyperleptinemia, hyperinsulinemia and dyslipidemia.
CONCLUSION: We conclude that; (i) the choice of disease-resistant inbred rat strains as ‘healthy controls’ for a disease-prone strain has to be carefully evaluated; (ii) in comparison with SHR, WOKW rats develop most if not all facets of the metabolic syndrome described in human and (iii) as with the human disease the syndrome in rats is polygenic.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Kesaniemi YA, Lilja M, Kervinen K, Rantala A . Multiple metabolic syndrome: aspects of genetic epidemiology and molecular genetics Ann Med 1992 24: 461–464.
Zimmet PZ, McCarty DJ, de Courten MP . The global epidemiology of non-insulin-dependent diabetes mellitus and the metabolic syndrome J Diabetes Complications 1997 11: 60–68.
Janka HU . Epidemiology of the metabolic syndrome Internist Berl 1996 37: 681–686.
Reaven GM, Chang H, Hoffman BB, Azhar S . Resistance to insulin-stimulated glucose uptake in adipocytes from spontaneously hypertensive rats Diabetes 1989 38: 1155–1160.
Hulman S, Falkner B, Chen YQ . Insulin resistance in the spontaneously hypertensive rat Metabolism 1991 40: 359–361.
Aitman TJ, Gotoda T, Evans AL, Imrie H, Heath KE, Trembling PM, Truman H, Wallace CA, Rahman A, Dore C, Flint J, Kren V, Zidek V, Kurtz TW, Pravenec M, Scott J . Quantitative trait loci for cellular defects in glucose and fatty acid metabolism in hypertensive rats Nature Genet 1997 16: 197–201.
Aitman TJ, Glazier AM, Wallace CA, Cooper LD, Norsworthy PJ, Wahid FN, Al Majali KM, Trembling PM, Mann CJ, Shoulders CC, Graf D, St Lezin E, Kurtz TW, Kren V, Pravenec M, Ibrahimi A, Abumrad NA, Stanton LW, Scott J . Identification of Cd36 (Fat) as an insulin-resistance gene causing defective fatty acid and glucose metabolism in hypertensive rats Nature Genet 1999 21: 76–83.
Kvetnansky R, Rusnak M, Gasperikova D, Jelokova J, Zorad S, Vietor I, Pacak K, Sebokova E, Macho L, Sabban EL, Klimes I . Hyperinsulinemia and sympathoadrenal system activity in the rat Ann NY Acad Sci 1997 827: 118–134.
Klimes I, Vrana A, Kunes J, Sebokova E, Dobesova Z, Stolba P, Zicha J . Hereditary hypertriglyceridemic rat: a new animal model of metabolic alterations in hypertension Blood Press 1995 4: 137–142.
Kovács P, Voigt B, Berg S, Vogt L, Klöting I . WOK. 1W rats. A potential animal model of the insulin resistance syndrome Ann N Y Acad Sci 1997 827: 94–99.
Kovács P, Samani NJ, Sebokova E, Voigt B, Gasperikova D, Jezova D, Kvetnansky R, Lodwick D, Klöting I, Klimes I . Phenotype and genotype comparison of hereditary hypertriglyceridemic (hHTG) and brown-Norway (BN) rats. Identification of quantitative trait loci (QTLs) for the insulin resistance syndrome Ann N Y Acad Sci 1997 827: 526–531.
Zicha J, Dobesova Z, Kunes J . Plasma triglycerides cosegregate with erythrocyte sodium content in F2 rats of HTG× Lewis cross Physiol Res 1995 44: 425–428.
Klöting I, Voigt B, Vogt L . Molecular analysis of diabetes-prone BB rat sublines and derivatives of their common ancestor as tool to search for candidate loci causing different phenotypes in BB rats Diabetes Res 1995 29: 65–71.
Klöting I, Vogt L . BB/O(ttawa) K(arlsburg) rats: features of a subline of diabetes-prone BB rats Diabetes Res 1991 18: 79–87.
Klöting I, Vogt L . 47 polymorphic microsatellite loci in different inbred rat strains J Exp Anim Sci 1995 37: 42–47.
Friedman JM, Halaas JL . Leptin and the regulation of body weight in mammals Nature 1998 395: 763–770.
Haller E . Eating disorders. A review and update West J Med 1992 157: 658–662.
Canzian F . Phylogenetics of the laboratory rat Rattus norvegicus Genome Res 1997 7: 262–267.
Bottger A, den Bieman M, Lankhorst AE, van Lith HA, van Zutphen LF . Strain-specific response to hypercholesterolaemic diets in the rat Lab Anim 1996 30: 149–157.
Bottger A, Lankhorst E, van Lith HA, van Zutphen LF, Zidek V, Musilova A, Simakova M, Poledne R, Bila V, Koen V, Pravenec M . A genetic and correlation analysis of liver cholesterol concentration in rat recombinant inbred strains fed a high cholesterol diet Biochem Biophys Res Commun 1998 246: 272–275.
Bottger A, van Lith HA, Kren V, Krenova D, Bila V, Vorlicek J, Zidek V, Musilova A, Zdobinska M, Wang JM, van Zutphen BF, Kurtz TW, Pravenec M . Quantitative trait loci influencing cholesterol and phospholipid phenotypes map to chromosomes that contain genes regulating blood pressure in the spontaneously hypertensive rat J Clin Invest 1996 98: 856–862.
Voigt B, Berg S, Kovács P, Vogt L, Klöting I . The metabolic X syndrome in derivatives of the progenitor strain of diabetes-prone BB rats Diabetologia 1996 39 (Suppl 1): A-153.
Kovács P, van den Brandt J, Klöting I . Genetic analysis of the metabolic syndrome in (WOKW and DA) F2 cross hybrids Diabetologia 1999 42 (Suppl 1): A-116.
van den Brandt J, Kovács P, Klöting I . Blood pressure, heart rate and motor activity in 6 inbred rat strains and wild rats (Rattus norvegicus): A comparative study Exp Anim 1999 48: 235–240.
Acknowledgements
We wish to thank Marlies Baumann, Edeltraut Lübke and Kathrin Stabenow for expert technical assistance. This work was supported by grant no. K1 771/3-1 of Deutsche Forschungsgemeinschaft.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
van den Brandt, J., Kovács, P. & Klöting, I. Metabolic features in disease-resistant as well as in spontaneously hypertensive rats and newly established obese Wistar Ottawa Karlsburg inbred rats. Int J Obes 24, 1618–1622 (2000). https://doi.org/10.1038/sj.ijo.0801444
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1038/sj.ijo.0801444
Keywords
This article is cited by
-
Rats of Hypertensive ISIAH Strain are Resistant to the Development of Metabolic Syndrome Induced by High-Fat Diet
Bulletin of Experimental Biology and Medicine (2014)
-
Metabolic syndrome markers in wistar rats of different ages
Diabetology & Metabolic Syndrome (2012)
-
Genes on Rat Chromosomes 3, 5, 10, and 16 Are Linked With Facets of Metabolic Syndrome
Obesity (2009)
-
Alleles on Rat Chromosome 4 (D4Got41-Fabp1/Tacr1) Regulate Subphenotypes of Obesity
Obesity Research (2005)
-
Metabolic syndrome and aging in Wistar Ottawa Karlsburg W rats
International Journal of Obesity (2002)