Abstract
The biological role(s) proposed for UCP3 in energy homeostasis have been based primarily upon amino acid sequence homology to UCP1. Spontaneous mutations of UCP3 have been described in humans, but not in rodents. The functional consequences—or lack thereof—of these mutations in humans will be of great importance in elucidating the biology of this protein. The results of two such studies are summarized here.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Chung, W., Luke, A., Cooper, R. et al. The long isoform uncoupling protein-3 (UCP3L) in human energy homeostasis. Int J Obes 23 (Suppl 6), S49–S50 (1999). https://doi.org/10.1038/sj.ijo.0800945
Published:
Issue Date:
DOI: https://doi.org/10.1038/sj.ijo.0800945
Keywords
This article is cited by
-
The mitochondrial uncoupling-protein homologues
Nature Reviews Molecular Cell Biology (2005)
-
Mice overexpressing human uncoupling protein-3 in skeletal muscle are hyperphagic and lean
Nature (2000)