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A schema for the anti-neuroinflammation effect of isosibiricin, a natural coumarin compound from medicinal plant Murraya exotica. Isosibiricin inhibits microglia-mediated neuroinflammation by selectively targeting dopamine D1/2 receptor-dependent NLRP3/caspase-1 inflammasome pathway. See the article in pages 173–180.