Volume 41 Issue 3, March 2020

Acetyl-CoA carboxylases (ACC1/ACC2) are important drug targets for NASH treatment. Gao et al developed WZ66, a novel inhibitor of ACCs that enables the decrease of de novo lipogenesis, the inactivation of Kupffer cells and hepatic stellate cells. WZ66 also altered the plasma lipids profile and gut microbiota composition.

Article

Discovery of aryl sulfonamide-selective Nav1.7 inhibitors with a highly hydrophobic ethanoanthracene core

Jin-tao Wang
Yue-ming Zheng
Fa-jun Nan
Article 17 Jul 2019
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Propofol affects mouse embryonic fibroblast survival and proliferation in vitro via ATG5- and calcium-dependent regulation of autophagy

Zhen-dong Xu
Yong Wang
Hua-feng Wei
Article 23 Oct 2019
α₁-AR overactivation induces cardiac inflammation through NLRP3 inflammasome activation

Jun-zhou Xin
Ji-min Wu
Li Wang
Article 17 Sept 2019
Kanglexin, a novel anthraquinone compound, protects against myocardial ischemic injury in mice by suppressing NLRP3 and pyroptosis

Yu Bian
Xin Li
Bao-feng Yang
Article 23 Oct 2019
23,24-Dihydrocucurbitacin B promotes lipid clearance by dual transcriptional regulation of LDLR and PCSK9

Hui-hui Li
Jun Li
Li-jiang Xuan
Article 29 Jul 2019
WZ66, a novel acetyl-CoA carboxylase inhibitor, alleviates nonalcoholic steatohepatitis (NASH) in mice

Ying-sheng Gao
Min-yi Qian
Li-rui Wang
Article 23 Oct 2019
A new recombinant MS-superoxide dismutase alleviates 5-fluorouracil-induced intestinal mucositis in mice

Xiao-xia Yan
Hai-long Li
Li-kun Gong
Article 10 Sept 2019
A novel compound AB38b attenuates oxidative stress and ECM protein accumulation in kidneys of diabetic mice through modulation of Keap1/Nrf2 signaling

Lei Du
Lei Wang
Qian Lu
Article 23 Oct 2019
Asiatic acid prevents renal fibrosis in UUO rats via promoting the production of 15d-PGJ2, an endogenous ligand of PPAR-γ

Zhi-hao Zhang
Jun-qiu He
Ning-hua Tan
Article 08 Nov 2019
Uncarboxylated osteocalcin ameliorates hepatic glucose and lipid metabolism in KKAy mice via activating insulin signaling pathway

Xiao-lin Zhang
Ya-nan Wang
Jian-hong Yang
Article 28 Oct 2019
RNF6 promotes myeloma cell proliferation and survival by inducing glucocorticoid receptor polyubiquitination

Ying Ren
Xin Xu
Xin-liang Mao
Article 23 Oct 2019
Xanthatin induces glioma cell apoptosis and inhibits tumor growth via activating endoplasmic reticulum stress-dependent CHOP pathway

Yu-yang Ma
Ze-min Di
Li-jie Feng
Article 07 Nov 2019
Discovery and biological evaluation of N-(3-(7-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)-4-methyl-2-oxo-2H-pyrimido[4,5-d][1,3]oxazin-1(4H)-yl)phenyl)acrylamide as potent Bruton’s tyrosine kinase inhibitors

Meng-zhen Lai
Pei-ran Song
Jian Ding
Article 17 Jul 2019
Discovery and characterization of natural products as novel indoleamine 2,3-dioxygenase 1 inhibitors through high-throughput screening

Wei Guo
Sheng Yao
Ling-hua Meng
Article 13 Jun 2019
Associating 197 Chinese herbal medicine with drug targets and diseases using the similarity ensemble approach

Shuo Gu
Lu-hua Lai
Article 17 Sept 2019

Volume 41 Issue 3, March 2020

Article

Discovery of aryl sulfonamide-selective Nav1.7 inhibitors with a highly hydrophobic ethanoanthracene core

Propofol affects mouse embryonic fibroblast survival and proliferation in vitro via ATG5- and calcium-dependent regulation of autophagy

α₁-AR overactivation induces cardiac inflammation through NLRP3 inflammasome activation

Kanglexin, a novel anthraquinone compound, protects against myocardial ischemic injury in mice by suppressing NLRP3 and pyroptosis

23,24-Dihydrocucurbitacin B promotes lipid clearance by dual transcriptional regulation of LDLR and PCSK9

WZ66, a novel acetyl-CoA carboxylase inhibitor, alleviates nonalcoholic steatohepatitis (NASH) in mice

A new recombinant MS-superoxide dismutase alleviates 5-fluorouracil-induced intestinal mucositis in mice

A novel compound AB38b attenuates oxidative stress and ECM protein accumulation in kidneys of diabetic mice through modulation of Keap1/Nrf2 signaling

Asiatic acid prevents renal fibrosis in UUO rats via promoting the production of 15d-PGJ2, an endogenous ligand of PPAR-γ

Uncarboxylated osteocalcin ameliorates hepatic glucose and lipid metabolism in KKAy mice via activating insulin signaling pathway

RNF6 promotes myeloma cell proliferation and survival by inducing glucocorticoid receptor polyubiquitination

Xanthatin induces glioma cell apoptosis and inhibits tumor growth via activating endoplasmic reticulum stress-dependent CHOP pathway

Discovery and biological evaluation of N-(3-(7-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)-4-methyl-2-oxo-2H-pyrimido[4,5-d][1,3]oxazin-1(4H)-yl)phenyl)acrylamide as potent Bruton’s tyrosine kinase inhibitors

Discovery and characterization of natural products as novel indoleamine 2,3-dioxygenase 1 inhibitors through high-throughput screening

Associating 197 Chinese herbal medicine with drug targets and diseases using the similarity ensemble approach

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