Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain
the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in
Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles
and JavaScript.
HeteroTCR extracts information on within-type (TCR-TCR or peptide-peptide) similarity and between-type (peptide-TCR) interaction from peptides and TCR input. It is robust across diverse datasets, affirming its potential in immunological applications.
An in-depth characterization of single-particle active microrheology via Acoustic Force Spectroscopy shows potential to measure viscoelastic moduli spanning five orders of magnitude and local heterogeneity in collagen gels and cells.
When used in CAR-T cell processing, the plant alkaloid berbamine prolongs the survival of leukemic animals by boosting CAR-T cell viability, memory phenotype, and persistence by modulating cellular metabolism, including mitochondrial respiration.
A study on the carbon sequestration capacity of soil in alpine grasslands across the Tibetan Plateau implies that warming will lead to an average increase of 7.49 mg/g microbial necromass carbon in topsoil, an increase of 68.3%.
Targeting conformally-active EGFR on small extracellular vesicles using a novel Charge-gated Ion Exchange Membrane sensor allows sensitive and non-invasive detection of Glioblastoma in human subjects from untreated plasma.
The transcription factor MNT binds to the SAT1 promoter region and represses its transcription, leading to ferroptosis and chemotherapy resistance in lung adenocarcinoma.
We implement SOFB, an ensemble deep learning model-based nucleic-acid-binding residues on proteins identification method to characterize protein sequences by learning the semantics of biological dynamics contexts.
The authors show that missense mutations in CCT2 evoked retinal photoreceptor degeneration with decreased expression levels of TRiC/CCT substrate proteins in the mouse retina.
A method to infer the modular organization of biological networks based on incomplete information. The method is based solely on observable network data and can be used to yield reconstructions of networks obtained from different data sources, such as cellular, genetic and brain measurements.
The authors present a multiplex, high-throughput method based on a commercially available multipipettor device to study mechanotransduction in cancer cells and immune cells in response to physiological fluid shear stress.
Introducing Microcket, a versatile toolkit for read alignment and interacting pair extraction from 3D genomics data (including Hi-C and Micro-C) with improved speed and sensitivity.
Current methods quantifying phage lytic efficacy have limits. Centroid Index quantifies efficacy via the center of area, offering more accuracy. For calculation of this index, a software called Centroid Index Calculator is presented.
Cryo-EM structure of human ATP-binding cassette transporter 6 (ABCB6) in complex with Cd(II) and glutathione (GSH) provides molecular insight into its dual role, essential for heme biosynthesis and as a heavy metal efflux pump.
IDO downregulation in dMDSCs induced by Toxoplasma gondii infection regulates expression of TGF-β and IL-10 through the Kyn/AhR/SP1 signal pathway, eventually contributing to the dysfunction of dNK cells.
A customized and shielded street lighting design significantly reduces the lethal attraction of flying insects in various environments. The approach harmonizes human needs with minimizing the ecological impact of artificial light at night.
A study on early life traumatic stress in mice suggest that changes in the fecal microbial community induced by early life stress can be perpetuated from exposed parent to the offspring across two generations.
Single-cell atlas of Microhyla fissipes lungs reveals cell differentiation and functionalization during metamorphosis, further cross-species comparison sheds light vertebrate lung cell type evolution.
This study reports sequencing, assembly, and characterization of the genome and transcriptome of Wolfiporia cocos. In addition, Three CYP450s were identified to be involved in the biosynthesis of its active component, pachymic acid.
A metagenomic analysis of 1,142 field-collected Anopheles gambiae mosquito specimens by the Microsoft Premonition Bayesian mixture model pipeline revealed a diverse set of vertebrate hosts, as well as the presence of Plasmodium parasites and other microbes.