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fMCI experiments on soft PDMS surfaces and mathematical models suggest that – in the low MPa range – increasing material compliance boosts neuron adhesion, clustering, and communication, impacting tissue engineering and regenerative medicine.
A DADA2 zebrafish model with cecr1b deficiency was generated. Characterization of hematopoietic processes revealed a role of Cecr1b in regulating inflammation and hematopoietic stem cell production through the A2br-mediated adenosine signaling.
This study illustrates consistent declines in shark functional richness which corresponds with declining ecological functioning and a community shift from targeted apex sharks to a greater functional richness of non-target species.
Single nucleus RNA-seq and spatial transcriptomics reveal a detailed picture of the cichlid fish forebrain. Comparisons with atlases in other vertebrates uncover striking transcriptional similarities and lend new insights into forebrain evolution.
A study on a soybean DNA demethylase reveals that seed size is negatively regulated by GmDMEa, which is closely linked to methylation on transposon elements.
An fMRI study using a new navigation task suggests that state inference with multi-layered uncertainty engages different areas of the medial prefrontal cortex and basal ganglia, depending on its level in the hierarchy and the nature of inference.
AlphaFold structure predictions uncover an unexpected connectedness between prokaryotic membrane transport proteins and two-component sensory kinases, thereby defining a large “transceptor” class of membrane proteins that have crossed the border between transporters and receptors.
Using primary mouse model of soft-tissue sarcoma (STS), authors show that sarcoma switches to glutamine metabolism post radiation therapy, and inhibition of glutaminolysis, either via genetic or pharmacological alterations, radiosensitizes STS in vivo.
Skeletal muscle-specific GDE5/Gpcpd1 deletion leads to glycerophosphocholine accumulation, which alters skeletal muscle phospholipid profiles and reduces passive force in electrically stimulated skeletal muscles in vivo.
A GWAS on 500 genetically diverse rice accessions enables identification of an allelic series for the unusual Ptr rice blast resistance gene, and the Pia resistance locus.
QUINT workflow analysis of cell and amyloid density in AD-BXD mice demonstrates age-dependent and strain-specific increases in gliosis and amyloid accumulation. These changes in brain composition influence age-related variations in gene expression.
A genome-wide association study on knee extension strength in 3452 persons of Japanese ancestry 60 years old and above identifies a significant association at a single locus that includes TACC2, a gene encoding a cytoskeleton-related protein.
An RNA sequencing study comparing juvenile cattle horn buds to growing deer antler tissues finds gene expression patterns that support homology of horns and antlers relative to a cranial-appendage-lacking outgroup.
Amplification in liposarcoma develops through a stepwise process that does not fit with classical chromothripsis. Depending on if and when telomeres from other chromosomes are captured, circularized or linear gain of 12q sequences will predominate.
Infant gray mouse lemurs performed better when they were born to mothers fed with dairy fat vs. vegetable fat in a set of tasks involving motor synchronization, sensory perception, learning and memory, suggesting an earlier psychomotor and cognitive development.
We analyzed the organ of Corti motions, component by component. Outer hair cells exploit their supporting cells to boost vibrations of the upper part of the organ of Corti while minimally disturbing the basilar membrane.
Dynamic processes of bacterial genome amplification involving a non-replicable but inheritable circular DNA molecule encoding multiple drug resistance proteins.
A study suggests that TBC9, one of the Rab GTPase Activating Proteins, is crucial for early vesicular transport and inner membrane complex formation by regulating Rab2, Rab11A and Rab11B in Toxoplasma gondii.