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What's taking so long? S-phase entry from quiescence versus proliferation

Nature Reviews Molecular Cell Biology volume 8, pages 667–670 (2007)Cite this article

Abstract

There is a short window in the mammalian cell cycle during which cells can respond to extracellular cues by withdrawing temporarily from the cell cycle. When these cells re-enter the cell cycle, they require several extra hours in the G1 phase before they replicate their DNA compared with their cycling counterparts. More than 20 years after this initial observation, we still do not understand what is taking so long.

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Figure 1: Progression through the mammalian cell cycle.
Figure 2: Retinoblastoma protein and cell-cycle progression.
Figure 3: The CDC6 on/off-chromatin model.

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Acknowledgements

H.A.C. is the Milton E. Cassel scholar of the Rita Allen Foundation. She is grateful to L. Fischer, L. Kruglyak and A. Legesse-Miller for helpful comments.

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  1. Hilary Coller is at the Department of Molecular Biology, Lewis Thomas Laboratory, Room 140, Princeton University, Princeton, New Jersey 08544-1014, USA. hcoller@princeton.edu,

    Hilary A. Coller

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Coller, H. What's taking so long? S-phase entry from quiescence versus proliferation. Nat Rev Mol Cell Biol 8, 667–670 (2007). https://doi.org/10.1038/nrm2223

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