Virus structures

Virus structures are the physical components of a virus particle, including its genome and structural proteins.

Latest Research and Reviews

  • Reviews |

    Respiratory syncytial virus (RSV) is a leading cause of lower respiratory tract disease in young children and elderly people. In this Review, Battles and McLellan summarize our current understanding of RSV entry, describe progress on the development of new interventions and conclude with a perspective on gaps in our knowledge that require further investigation.

    • Michael B. Battles
    •  & Jason S. McLellan
  • Research | | open

    Nucleocytoplasmic large DNA viruses are a group of viruses that infect many eukaryotic hosts. Here, the authors provide a 3.5 Å resolution icosahedrally-averaged capsid structure of Paramecium bursaria chlorella virus 1 and show how 1800 minor capsid proteins form a hexagonal network below the outer capsid shell.

    • Qianglin Fang
    • , Dongjie Zhu
    • , Irina Agarkova
    • , Jagat Adhikari
    • , Thomas Klose
    • , Yue Liu
    • , Zhenguo Chen
    • , Yingyuan Sun
    • , Michael L. Gross
    • , James L. Van Etten
    • , Xinzheng Zhang
    •  & Michael G. Rossmann
  • Research |

    Cryo-electron microscopy structures of feline calicivirus and its cellular receptor show that twelve copies of the minor capsid protein VP2 form a portal-like assembly arranged about a pore in the capsid shell.

    • Michaela J. Conley
    • , Marion McElwee
    • , Liyana Azmi
    • , Mads Gabrielsen
    • , Olwyn Byron
    • , Ian G. Goodfellow
    •  & David Bhella
    Nature 565, 377-381
  • Research | | open

    More than 18 human papillomaviruses (HPV) are associated with cervical cancer, and ideally vaccines should protect from all of them. Here, the authors engineer a triple-type, chimeric HPV vaccine, using loop swapping, that elicits robust neutralizing antibody titers in mice and non-human primates.

    • Zhihai Li
    • , Shuo Song
    • , Maozhou He
    • , Daning Wang
    • , Jingjie Shi
    • , Xinlin Liu
    • , Yunbing Li
    • , Xin Chi
    • , Shuangping Wei
    • , Yurou Yang
    • , Zhiping Wang
    • , Jinjin Li
    • , Huilian Qian
    • , Hai Yu
    • , Qingbing Zheng
    • , Xiaodong Yan
    • , Qinjian Zhao
    • , Jun Zhang
    • , Ying Gu
    • , Shaowei Li
    •  & Ningshao Xia
  • Research | | open

    Alphaviruses are enveloped RNA viruses that contain several human pathogens. Here, the authors use block-based reconstruction method and provide a 3.5 Å cryo-EM structure of sindbis virus that identifies a conserved hydrophobic pocket near the viral membrane that is stabilized by an unknown pocket factor.

    • Lihong Chen
    • , Ming Wang
    • , Dongjie Zhu
    • , Zhenzhao Sun
    • , Jun Ma
    • , Jinglin Wang
    • , Lingfei Kong
    • , Shida Wang
    • , Zaisi Liu
    • , Lili Wei
    • , Yuwen He
    • , Jingfei Wang
    •  & Xinzheng Zhang
  • Reviews |

    Many phages use tails to attach to and penetrate the cell envelope of their bacterial hosts. In this Review, Brouns and colleagues explore recent structural and mechanistic insights into the interaction of phage tails with receptors on the bacterial surface.

    • Franklin L. Nobrega
    • , Marnix Vlot
    • , Patrick A. de Jonge
    • , Lisa L. Dreesens
    • , Hubertus J. E. Beaumont
    • , Rob Lavigne
    • , Bas E. Dutilh
    •  & Stan J. J. Brouns

News and Comment